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Interaction of phospholipid bilayers with polyamines of different length

  • BIOPHYSICS LETTER
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Abstract

The tip-dip patch clamp method was used to study the effect of three polyamines, putrescine, spermidine and spermine, on bilayer lipid membrane (BLM) stability. Two kinds of mixed lipid-polyamine membranes were investigated. The poration voltage (V p), and the closed (σcl) and open (σop) state conductances for pure and polyamine-treated lipid membranes were determined by the method of current-voltage surfaces. It was demonstrated that putrescine and spermidine destabilized lipid membranes under all circumstances. BLM stabilization by spermine was observed when it was added to preformed membranes.

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Authors and Affiliations

  1. Biomolecular Layers Department, Institute of Solid State Physics, Bulgarian Academy of Sciences, 1784 Sofia, Bulgaria e-mail: georgant@issp.bas.bg, , , , , , BG

    A. Zheliaskova, S. Naydenova & A.G. Petrov

Authors
  1. A. Zheliaskova
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  2. S. Naydenova
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  3. A.G. Petrov
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Additional information

Received: 19 November 1999 / Revised version: 25 February 2000 / Accepted: 25 February 2000

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Zheliaskova, A., Naydenova, S. & Petrov, A. Interaction of phospholipid bilayers with polyamines of different length. Eur Biophys J 29, 153–157 (2000). https://doi.org/10.1007/s002490050261

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  • DOI: https://doi.org/10.1007/s002490050261

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