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Usefulness of central radiologic review in clinical trials of children with hepatoblastoma

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Abstract

Background

No previous research papers have reported a comparative survey of local radiologic diagnoses and central review in children with hepatoblastoma.

Objective

To evaluate the utility of central review of children with hepatoblastoma enrolled in a clinical trial.

Materials and methods

The study included 91 children enrolled in a clinical trial conducted by the Japanese Study Group for Pediatric Liver Tumor. We compared the results of the initial pre-treatment extent of tumor (PRETEXT) disease staging performed at local sites with the results obtained on central review to determine the concurrence rates for tumor staging and additional criteria.

Results

The concurrence rate for PRETEXT staging was 70%. As the stage increased, the concurrence rate decreased. Using additional criteria, central review identified 143 lesions (157.1%), about 1.8 times higher than the number identified for the local site diagnoses. The additional criterion found most often on central review was “multifocal lesion” (n=19). The concurrence rate for lung metastases was high. However, our central review found many false-positive assertions of hepatic vein lesions, portal vein invasion and extrahepatic lesions among the local site diagnoses.

Conclusion

In a clinical trial of hepatoblastoma, central review provided a more precise diagnosis than local site diagnoses with respect to severe PRETEXT stages III and IV cases and other cases including hepatic and portal vein invasion. The central review process appears to be effective and essential for improving the quality of clinical trials.

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Acknowledgments

The authors would like to thank Dr. Yoshitomo Matsuo and Ban Asatsuma for technical support with respect to a cloud-based teleradiology system (Esite Healthcare Co., Tokyo, Japan). The authors appreciate the contributions made by all of the physician members of the Japan Children’s Cancer Group (JCCG) and liver tumor committee. We thank Mrs. Hiroe Saito, Mrs. Rika Kashihara and Mrs. Minako Mase for office work in the radiology committee of the JCCG. This work was supported by the Japan Agency for Medical Research and Development (AMED) under grant numbers 17ck0106332h, 20ck0106609h and 20lk0201066h, and the Japanese Society for the Promotion of Science (JSPS KAKENHI) under grant number JP16H02778.

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Authors and Affiliations

  1. Radiology Committee, Pediatric Liver Tumor Group, Japan Children’s Cancer Group, Tokyo, Japan

    Osamu Miyazaki, Eiji Oguma, Masanori Nishikawa, Yutaka Tanami, Takahiro Hosokawa, Masahiro Kitami, Hidekazu Aoki, Shinya Hattori & Ken Motoori

  2. Department of Radiology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan

    Osamu Miyazaki & Masayuki Kitamura

  3. Department of Radiology, Saitama Children’s Medical Center, Saitama, Japan

    Eiji Oguma, Yutaka Tanami & Takahiro Hosokawa

  4. Department of Radiology, Osaka Women’s and Children’s Hospital, Osaka, Japan

    Masanori Nishikawa

  5. Department of Radiology, Miyagi Children’s Hospital, Sendai, Miyagi, Japan

    Masahiro Kitami

  6. Department of Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan

    Hidekazu Aoki

  7. Department of Radiology, Chiba University Graduate School of Medicine, Chiba, Japan

    Shinya Hattori

  8. Department of Radiology, Tsudanuma Central General Hospital, Narashino, Japan

    Ken Motoori

  9. Liver Tumor Committee, Japan Children’s Cancer Group (JCCG), Hiroshima, Japan

    Kenichiro Watanabe, Kohmei Ida, Tomoro Hishiki & Eiso Hiyama

  10. Department of Hematology and Oncology, Shizuoka Children’s Hospital, Shizuoka, Japan

    Kenichiro Watanabe

  11. Department of Pediatrics, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan

    Kohmei Ida

  12. Department of Pediatric Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

    Tomoro Hishiki

  13. Radiology Committee, Japan Children’s Cancer Group, Tokyo, Japan

    Masayuki Kitamura & Kumiko Nozawa

  14. Department of Radiology, Kanagawa Children’s Medical Center, Yokohama, Japan

    Kumiko Nozawa

  15. Department of Childhood Cancer Data Management, National Center for Child Health and Development, Tokyo, Japan

    Tetsuya Takimoto

  16. Natural Science Center for Basic Research and Development, Department of Pediatric Surgery, Hiroshima University, Hiroshima, Japan

    Eiso Hiyama

Authors
  1. Osamu Miyazaki
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  2. Eiji Oguma
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  3. Masanori Nishikawa
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  4. Yutaka Tanami
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  5. Takahiro Hosokawa
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  6. Masahiro Kitami
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  7. Hidekazu Aoki
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  8. Shinya Hattori
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  9. Ken Motoori
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  10. Kenichiro Watanabe
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  11. Kohmei Ida
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  12. Tomoro Hishiki
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  13. Masayuki Kitamura
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  14. Kumiko Nozawa
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  15. Tetsuya Takimoto
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  16. Eiso Hiyama
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Corresponding author

Correspondence to Osamu Miyazaki.

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Miyazaki, O., Oguma, E., Nishikawa, M. et al. Usefulness of central radiologic review in clinical trials of children with hepatoblastoma. Pediatr Radiol 53, 367–377 (2023). https://doi.org/10.1007/s00247-022-05530-4

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  • DOI: https://doi.org/10.1007/s00247-022-05530-4

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