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Semiquantitative characterization of dynamic magnetic resonance perfusion of the liver in pediatric Fontan patients

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Abstract

Background

Dynamic contrast-enhanced magnetic resonance imaging (MRI) of the liver in pediatric Fontan patients often shows peripheral reticular areas of hypoenhancement, which has not been studied in detail.

Objective

To semiquantitatively score the hepatic MR perfusion abnormality seen in pediatric Fontan patients, and to correlate the perfusion abnormality with functional clinical and hemodynamic parameters.

Materials and methods

All children (< 18 years old) after Fontan palliation with combined clinical cardiac and liver MRI performed between May 2017 and April 2019 were considered for inclusion. A semiquantitative perfusion score was used to assess the severity of the hepatic reticular pattern seen on dynamic contrast-enhanced liver imaging. The liver was divided into four sections: right posterior, right anterior, left medial and left lateral. Each liver section was assigned a score from 0 to 4 depending on the amount of abnormal reticular hypoenhancement. Scoring was assigned for each section of the liver across eight successive dynamic contrast-enhanced modified spoiled gradient echo runs. Scores were correlated with clinical and hemodynamic parameters.

Results

All Fontan children showed hepatic reticular hypoenhancement by MRI, most severe in the early portal venous phase with a median maximum total perfusion abnormality score of 12 (range: 9–14). All perfusion abnormalities progressively resolved during the hepatic venous phase. Perfusion abnormality scores were greatest in the right compared to left hepatic lobes (7 range: [6–8] vs. 5 [range: 3–6], P < 0.01). The maximum left hepatic lobe perfusion abnormality scores were greatest in children with versus without imaging signs of portal hypertension (8 [range: 7–8] vs. 4 [range: 3–5], P < 0.01). High unconjugated bilirubin and low platelets correlated with greater perfusion abnormality (R = 0.450, P = 0.024, and R =  − 0.458, P < 0.01, respectively). Age at MRI, time from Fontan, focal liver lesions and cardiac MRI hemodynamic parameters did not show significant correlations with the severity of the liver perfusion abnormality.

Conclusion

All Fontan children have hepatic reticular hypoenhancement abnormalities seen with MRI that are most severe in the right hepatic lobe and universally show gradual resolution through the hepatic venous phase. Perfusion abnormality in the left hepatic lobe is worse in children with portal hypertension.

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Acknowledgements

The authors acknowledge the Ontasian Imaging Lab for administrative and statistical support.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada

    María Navallas, Shi-Joon Yoo, Govind B. Chavhan, Afsaneh Amirabadi & Christopher Z. Lam

  2. Division of Pediatric Imaging, Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada

    María Navallas, Shi-Joon Yoo, Govind B. Chavhan, Afsaneh Amirabadi & Christopher Z. Lam

  3. Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada

    Shi-Joon Yoo & Michael Seed

  4. Division of Gastroenterology, Hepatology & Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada

    Simon C. Ling

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  1. María Navallas
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Correspondence to María Navallas.

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Navallas, M., Yoo, SJ., Chavhan, G.B. et al. Semiquantitative characterization of dynamic magnetic resonance perfusion of the liver in pediatric Fontan patients. Pediatr Radiol 52, 483–492 (2022). https://doi.org/10.1007/s00247-021-05221-6

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  • DOI: https://doi.org/10.1007/s00247-021-05221-6

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