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Surveillance imaging in pediatric lymphoma

  • Pediatric oncologic imaging
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Abstract

Current therapies used in treating children with Hodgkin lymphoma and many histological subtypes of non-Hodgkin lymphoma have resulted in overall survival rates exceeding 90% in many instances. With increasing concerns related to the cost of radiologic imaging, exposure to ionizing radiation, and potential false-positive results, the role of routine off-therapy surveillance imaging has been called into question. Although radiologic imaging plays an important role in diagnosing and assessing treatment response, in these children — the majority of whom have an excellent outcome following completion of therapy — there is an opportunity to dramatically reduce the number of off-therapy imaging evaluations. This review summarizes several recent studies in both Hodgkin and non-Hodgkin lymphoma providing evidence to support these efforts. In addition, we propose a surveillance imaging strategy that uses a novel risk-adapted and response-based approach to determine which children would most benefit from off-therapy imaging surveillance.

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Acknowledgments

The authors would like to thank Erin Morris, RN, for her expert assistance in the preparation of the manuscript. Dr. Cairo was supported by the Pediatric Cancer Research Foundation and the Marisa Fund.

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Authors and Affiliations

  1. Department of Radiology, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Stephan D. Voss

  2. Department of Pediatric Hematology,Oncology, and Stem Cell Transplantation, Maria Fareri Children’s Hospital, Westchester Medical Center, New York Medical College, Valhalla, NY, USA

    Mitchell S. Cairo

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  1. Stephan D. Voss
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  2. Mitchell S. Cairo
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Correspondence to Stephan D. Voss.

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Voss, S.D., Cairo, M.S. Surveillance imaging in pediatric lymphoma. Pediatr Radiol 49, 1565–1573 (2019). https://doi.org/10.1007/s00247-019-04511-4

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