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Pancreatic tumors in children and young adults with tuberous sclerosis complex

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Abstract

Background

Pancreatic neuroendocrine tumors are not included in the diagnostic criteria for tuberous sclerosis complex, although an association has been described.

Objective

To investigate the association of pancreatic neuroendocrine tumor in children and young adults with tuberous sclerosis complex and define MRI characteristics of the tumor.

Materials and methods

We retrospectively evaluated the abdominal MRI scans of 55 children and young adults with tuberous sclerosis complex for the presence of a pancreatic mass. The scans were performed over a period of 7 years to monitor renal pathology. We obtained each patient’s clinical history and treatment protocol from the hospital’s electronic medical records.

Results

A solid pancreatic mass was identified in 5/55 (9%, 95% confidence interval [CI] 3–20%) patients (4 male) with a mean age of 12.6 years. Four of the lesions were located in the pancreatic tail and one in the pancreatic body. All of the lesions were solid, ovoid and well demarcated, with a mean diameter of 3.1 cm. The masses uniformly demonstrated T1 and T2 prolongation, but their diffusion behavior and post-contrast enhancement varied. The two surgically resected lesions were synaptophysin (+) non-functional pancreatic neuroendocrine tumors on pathology. Two of the patients who did not have surgery were treated with everolimus; one of the lesions has shown interval decrease in size and the other has remained stable.

Conclusion

Pancreatic tumor is relatively common in children and young adults with tuberous sclerosis complex.

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Authors and Affiliations

  1. Erciyes University, School of Medicine, Department of Pediatric Radiology, Melikgazi, 38039, Kayseri, Turkey

    Gonca Koc

  2. Department of Diagnostic Imaging, UCSF Benioff Children’s Hospital, Oakland, CA, USA

    Sam Sugimoto, Bamidele F. Kammen & S. Pinar Karakas

  3. Department of Pediatric Neurology, UCSF Benioff Children’s Hospital, Oakland, CA, USA

    Rachel Kuperman

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  1. Gonca Koc
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  2. Sam Sugimoto
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  3. Rachel Kuperman
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  4. Bamidele F. Kammen
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  5. S. Pinar Karakas
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Correspondence to Gonca Koc.

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Koc, G., Sugimoto, S., Kuperman, R. et al. Pancreatic tumors in children and young adults with tuberous sclerosis complex. Pediatr Radiol 47, 39–45 (2017). https://doi.org/10.1007/s00247-016-3701-0

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  • DOI: https://doi.org/10.1007/s00247-016-3701-0

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