Skip to main content

Advertisement

SpringerLink
Log in

Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation

  • Original Article
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Background

Angiomatoid fibrous histiocytoma is a rare soft-tissue tumor that more often affects children and young adults. There is little information available regarding the imaging appearance of angiomatoid fibrous histiocytoma in children.

Objective

To describe the ultrasonographic (US) and magnetic resonance (MR) imaging findings of angiomatoid fibrous histiocytoma in children.

Materials and methods

A retrospective analysis was done of US and MR imaging findings in children with angiomatoid fibrous histiocytoma. Clinical findings and histopathology with molecular analysis results were also collected.

Results

There were 7 children with angiomatoid fibrous histiocytoma with a median age of 6 years (age range: 16 months-14 years). Patients presented clinically with a soft-tissue mass in the extremities or in the trunk. Four children had anemia, and three of them had additional systemic symptoms. Two patients had US and three had MR imaging while the remaining two had both. Lesion size ranged from 1.3 cm to 7.2 cm. In four patients, angiomatoid fibrous histiocytoma presented as a nonspecific predominantly solid mass. The other three patients had a combination of the following imaging findings: intralesional blood-filled cystic spaces with fluid-fluid levels, enhancing fibrous pseudocapsule and hemosiderin deposition. These findings correlated well with histopathology.

Conclusion

The imaging detection of intralesional blood-filled cystic spaces with fluid-fluid levels, enhancing fibrous pseudocapsule and hemosiderin deposition in a soft-tissue tumor in a child may suggest the diagnosis of angiomatoid fibrous histiocytoma. A history of systemic symptoms and anemia in the presence of a soft-tissue mass may also be a clue for the diagnosis of angiomatoid fibrous histiocytoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Notes

  1. Ewing sarcoma gene/activating transcription factor 1

  2. Cyclic AMP response element binding protein 1

  3. Ewing sarcoma breakpoint region 1

  4. Fused in sarcoma

References

  1. Antonescu CR, Rossi S (2013) Angiomatoid fibrous histiocytoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) WHO classification of tumours of soft tissue and bone, 4th edn. IARC Press, Lyon, pp 204–205

    Google Scholar 

  2. Enzinger FM (1979) Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer 44:2147–2157

    Article  CAS  PubMed  Google Scholar 

  3. Patrizi A, Tabanelli M, Filippi G et al (2010) An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. Dermatol Online J 16:4

    PubMed  Google Scholar 

  4. Chen G, Folpe AL, Colby TV et al (2011) Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol 24:1560–1570

    Article  CAS  PubMed  Google Scholar 

  5. Murphey MD, Gross TM, Rosenthal HG (1994) From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. Radiographics 14:807–826

    Article  CAS  PubMed  Google Scholar 

  6. Li CS, Chan WP, Chen WT (2004) MRI of angiomatoid fibrous histiocytoma. Skeletal Radiol 33:604–608

    Article  PubMed  Google Scholar 

  7. Koletsa T, Hytiroglou P, Semoglou C et al (2007) Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin. Pathol Int 57:513–516

    Article  PubMed  Google Scholar 

  8. Choi JH, Sung WJ, Lee NH (2007) Angiomatoid fibrous histiocytoma: a case report. Yeungnam Univ J Med 24:315–321

    Google Scholar 

  9. Ajlan AM, Sayegh K, Powell T (2010) Angiomatoid fibrous histiocytoma: magnetic resonance imaging appearance in 2 cases. J Comput Assist Tomogr 34:791–794

    Article  PubMed  Google Scholar 

  10. Mansfield A, Larson B, Stafford SL et al (2010) Angiomatoid fibrous histiocytoma in a 25-year-old male. Rare Tumors 2:e20

    Article  PubMed Central  PubMed  Google Scholar 

  11. Makis W, Ciarallo A, Hickeson M et al (2011) Angiomatoid fibrous histiocytoma: staging and evaluation of response to therapy with F-18 FDG PET/CT. Clin Nucl Med 36:376–379

    Article  PubMed  Google Scholar 

  12. Bauer A, Jackson B, Marner E et al (2012) Angiomatoid fibrous histiocytoma: a case report and review of the literature. J Radiol Case Rep 6:8–15

  13. Hata H, Natsuga K, Aoyagi S et al (2014) Ultrasound B-mode and elastographic findings of angiomatoid fibrous histiocytoma. Clin Exp Dermatol 39:538–539

    Article  CAS  PubMed  Google Scholar 

  14. Ibrahim DA, Mascarenhas L, Tovar JP et al (2013) Orthopaedic case of the month: a 14-year-old boy with a medial thigh soft tissue mass. Clin Orthop Relat Res 471:1433–1438

    Article  PubMed Central  PubMed  Google Scholar 

  15. Lee HS, Kim T, Kim JS et al (2013) Angiomatoid fibrous histiocytoma as a second tumor in a young adult with testicular cancer. Cancer Res Treat 45:239–243

    Article  PubMed Central  PubMed  Google Scholar 

  16. Fletcher CD (2014) The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification. Histopathology 64:2–11

    Article  PubMed  Google Scholar 

  17. Schaefer IM, Fletcher CD (2014) Myxoid variant of so-called angiomatoid “malignant fibrous histiocytoma”: clinicopathologic characterization in a series of 21 cases. Am J Surg Pathol 38:816–823

    Article  PubMed  Google Scholar 

  18. Daw NC, Billups CA, Pappo AS et al (2003) Malignant fibrous histiocytoma and other fibrohistiocytic tumors in pediatric patients: the St. Jude Children’s Research Hospital experience. Cancer 97:2839–2847

    Article  PubMed  Google Scholar 

  19. Costa MJ, Weiss SW (1990) Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol 14:1126–1132

    Article  CAS  PubMed  Google Scholar 

  20. Thway K (2008) Angiomatoid fibrous histiocytoma: a review with recent genetic findings. Arch Pathol Lab Med 132:273–277

    PubMed  Google Scholar 

  21. Tanas MR, Rubin BP, Montgomery EA et al (2010) Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases. Mod Pathol 23:93–97

    Article  CAS  PubMed  Google Scholar 

  22. Navarro OM, Laffan EE, Ngan BY (2009) Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 1. Imaging approach, pseudotumors, vascular lesions and adipocytic tumors. Radiographics 29:887–906

    Article  PubMed  Google Scholar 

  23. Laffan EE, Ngan BY, Navarro OM (2009) Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics 29:e36

    Article  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada

    Ali Yikilmaz & Oscar M. Navarro

  2. Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada

    Bo-Yee Ngan

Authors
  1. Ali Yikilmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bo-Yee Ngan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Oscar M. Navarro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oscar M. Navarro.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yikilmaz, A., Ngan, BY. & Navarro, O.M. Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation. Pediatr Radiol 45, 1796–1802 (2015). https://doi.org/10.1007/s00247-015-3404-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-015-3404-y

Keywords

Search

Navigation