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Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography

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Abstract

Background

Pediatric contrast-enhanced MR angiography is often limited by respiration, other patient motion and compromised spatiotemporal resolution.

Objective

To determine the reliability of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography method for depicting abdominal arterial anatomy in young children.

Materials and methods

With IRB approval and informed consent, we retrospectively identified 27 consecutive children (16 males and 11 females; mean age: 3.8 years, range: 14 days to 8.4 years) referred for contrast-enhanced MR angiography at our institution, who had undergone free-breathing spatiotemporally accelerated time-resolved contrast-enhanced MR angiography studies. A radio-frequency-spoiled gradient echo sequence with Cartesian variable density k-space sampling and radial view ordering, intrinsic motion navigation and intermittent fat suppression was developed. Images were reconstructed with soft-gated parallel imaging locally low-rank method to achieve both motion correction and high spatiotemporal resolution. Quality of delineation of 13 abdominal arteries in the reconstructed images was assessed independently by two radiologists on a five-point scale. Ninety-five percent confidence intervals of the proportion of diagnostically adequate cases were calculated. Interobserver agreements were also analyzed.

Results

Eleven out of 13 arteries achieved acceptable image quality (mean score range: 3.9-5.0) for both readers. Fair to substantial interobserver agreement was reached on nine arteries.

Conclusion

Free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography frequently yields diagnostic image quality for most abdominal arteries in young children.

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Acknowledgments

This work was supported by NIH grants R01 EB009690, R01 EB019241, P41 EB015891, the Tashia and John Morgridge Faculty Scholars Fund and GE Healthcare.

Conflicts of interest

T. Zhang, J. Y. Cheng, M. T. Alley, M. Lustig, J. M. Pauly and S. S. Vasanawala collaborate on research with GE Healthcare.

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Authors and Affiliations

  1. Department of Radiology, Stanford University, 350 Serra Mall, Packard 212, Stanford, CA, 94305, USA

    Tao Zhang, Ufra Yousaf, Joseph Y. Cheng, Marcus T. Alley & Shreyas S. Vasanawala

  2. Department of Electrical Engineering, Stanford University, Stanford, CA, USA

    Tao Zhang, Joseph Y. Cheng, Michael Lustig & John M. Pauly

  3. Department of Radiology, University of California, San Diego, San Diego, CA, USA

    Albert Hsiao

  4. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA

    Michael Lustig

Authors
  1. Tao Zhang
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  2. Ufra Yousaf
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  3. Albert Hsiao
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  4. Joseph Y. Cheng
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  5. Marcus T. Alley
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  8. Shreyas S. Vasanawala
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Correspondence to Tao Zhang.

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Zhang, T., Yousaf, U., Hsiao, A. et al. Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography. Pediatr Radiol 45, 1635–1643 (2015). https://doi.org/10.1007/s00247-015-3384-y

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