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Congenital infantile fibrosarcoma: review of imaging features

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Abstract

Background

Fibrosarcoma is a rare tumor in children with limited information on imaging features of these tumors in the literature.

Objective

To retrospectively review the imaging features of histologically proven congenital infantile fibrosarcoma.

Materials and methods

The list of histologically confirmed congenital infantile fibrosarcomas between November 1999 and June 2013 was obtained from the oncology-pathology database. Imaging features and pathology reports of these tumors were reviewed. Patient charts were reviewed and clinical features, management and outcomes were recorded.

Results

During the study period, 13 children (9 girls and 4 boys; age range: 0 day–16 months, median age: 2.5 months) with congenital infantile fibrosarcomas were available for complete radiological review. The translocation (t[12;15]) was present in 11/13 (84.6%) and absent in 2/13. Eight/thirteen (61.5%) tumors were located in extremities (5 in lower and 3 in upper), 3/13 in thoracolumbar paraspinal regions, and one each in abdomen and sternocleidomastoid muscle. Imaging features included iso- to hyperintensity on T1-W, hyperintensity on T2-W as compared to skeletal muscles and heterogeneous enhancement. Six (37.5%) tumors showed hemorrhagic components and 2 (15.4%) showed low intensity foci. None of the patients had evidence of regional or distant metastases at diagnosis. Management included surgical resection only (1/13) and combined surgery and chemotherapy (10/13). Overall survival was 100% with a median follow-up of 49.3 months.

Conclusion

Congenital infantile fibrosarcoma has nonspecific imaging characteristics but should be high on the differential diagnosis in a soft-tissue tumor presenting in infancy, located in an extremity and showing tumoral hemorrhage. Patients have a favorable outcome.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, McMaster University Medical Centre and McMaster University, Hamilton, ON, Canada

    Kelly E. Ainsworth

  2. Department of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada

    Govind B. Chavhan

  3. Division of Pediatric Hematology and Oncology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada

    Abha A. Gupta

  4. Division of Orthopaedics, and Developmental and Stem Cell Biology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada

    Sevan Hopyan

  5. Pediatric Laboratory Medicine, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada

    Glenn Taylor

Authors
  1. Kelly E. Ainsworth
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  2. Govind B. Chavhan
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  3. Abha A. Gupta
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  4. Sevan Hopyan
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  5. Glenn Taylor
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Correspondence to Govind B. Chavhan.

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Ainsworth, K.E., Chavhan, G.B., Gupta, A.A. et al. Congenital infantile fibrosarcoma: review of imaging features. Pediatr Radiol 44, 1124–1129 (2014). https://doi.org/10.1007/s00247-014-2957-5

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  • DOI: https://doi.org/10.1007/s00247-014-2957-5

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