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Cross-Sectional Analysis of Cardiovascular Risk Factors in Children With Parental History of Premature Ischemic Heart Disease

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Abstract

This study aimed to evaluate the presence of cardiovascular risk factors in children with a parental history of premature ischemic heart disease (two- or three-vessel disease diagnosed before the age of 55 in men and 65 in women). A prospective cross-sectional study was performed on 55 children. The following parameters were assessed: body mass index (BMI), waist and hip circumference, blood pressure, lipids profile, fasting glucose (FG), C-reactive protein (CRP), and carotid intimal-medial thickness (CIMT). Twenty-eight children had hypercholesterolemia, and 11 had other forms of dyslipidemia. Sixteen children had a high BMI; 17 had increased CRP levels; 2 were hypertensive; and 2 had impaired FG. CIMT levels were not correlated with age (Pearson r = −0.486; p = 0.78) and height (Pearson r = −6.31; p = 0.84), but they were correlated with cholesterol levels (Spearman r = 0.375; p < 0.005). Most patients (83%) had ≥2 risk factors; half of them had ≥3 risk factors. We concluded that these at-risk children should be carefully screened for all known risk factors.

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Acknowledgment

We thank Michal Rosenberg, Pediatric Clinical Dietician, for her ongoing help on this project.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatrics, Meyer Children’s Hospital, Rambam Health Care Campus, Haifa, Israel

    Gal Neuman, Itai Shavit, Roy Onn & Naim Shehadeh

  2. Technion Faculty of Medicine, Haifa, Israel

    Gal Neuman, Itai Shavit, Doron Aronson, Avraham Lorber, Diana Gaitini, Roy Onn & Naim Shehadeh

  3. Department of Cardiology, Rambam Health Care Campus, Haifa, Israel

    Doron Aronson

  4. Department of Pediatric Cardiology, Meyer Children’s Hospital, Rambam Health Care Campus, Haifa, Israel

    Avraham Lorber

  5. Department of Medical Imaging, Rambam Health Care Campus, Haifa, Israel

    Diana Gaitini

  6. P.O. Box 369, 22103, Nahariya, Israel

    Itai Shavit

Authors
  1. Gal Neuman
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  2. Itai Shavit
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  3. Doron Aronson
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  4. Avraham Lorber
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  5. Diana Gaitini
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  6. Roy Onn
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  7. Naim Shehadeh
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Correspondence to Itai Shavit.

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Neuman, G., Shavit, I., Aronson, D. et al. Cross-Sectional Analysis of Cardiovascular Risk Factors in Children With Parental History of Premature Ischemic Heart Disease. Pediatr Cardiol 32, 628–633 (2011). https://doi.org/10.1007/s00246-011-9931-x

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  • DOI: https://doi.org/10.1007/s00246-011-9931-x

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