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Time- and Tissue-Dependent Polychlorinated Biphenyl Residues in Hairless Mice After Exposure to Polychlorinated Biphenyl-Contaminated Soil

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Abstract

Four groups of 16 age-matched female Crl:SKH1-hrBR hairless mice were exposed to either control soil or polychlorinated biphenyl (PCB)–contaminated soil (retrieved from an electrical waste landfill in Southern Illinois) for 11 weeks. The mice were exposed in a study to determine interactions between environmental PCBs and ultraviolet radiation (UVR), but the UVR group did not differ and provided a replicate for the residue study. Ear biopsies were performed immediately after the termination of soil exposure. The mice were maintained in regular bedding for 37 weeks thereafter. The ear-skin, trunk-skin, fat-pad, and liver samples were collected and weighed at the end of the study (week 48) and analyzed for PCB residues. A total of 141 PCB congeners were target analytes. There were significant differences in body weights and food consumption from week 2 to 28. The liver weights of mice treated with PCB only were significantly greater than those of UVR-treated mice. The fat-pad weight did not differ among treated groups. PCB residues in the ear biopsies specimens of mice exposed to contaminated soil were 342.3 and 317.2 ppm in the PCB- and PCB + UVR–treated groups, respectively, and contained both persistent and episodic congeners. After 37 weeks of isolation from soil, the ear PCB residues decreased to 21.5 ppm (PCB group) and 14.5 ppm (PCB + UVR group), and only persistent congeners contributed to the total PCB residues. The accumulation of PCB residues was highest in the fat pad (fat pad > ear skin > trunk skin > liver) in both PCB ± UVR groups at the end of the study. However, the percentage of individual congeners contributing to total PCBs in these different tissues did not differ.

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Authors and Affiliations

  1. Department of Veterinary Biosciences, University of Illinois, 2001 S. Lincoln Ave., Urbana, Illinois, 61802, USA

    K. Imsilp, C. K. Morrow & L. G. Hansen

  2. Illinois Waste Management and Research Center, One Hazelwood Dr., Champaign, Illinois, 61820, USA

    L. Wiedenmann, G. O. Bordson & R. Cope

Authors
  1. K. Imsilp
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  2. L. Wiedenmann
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  3. G. O. Bordson
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  4. C. K. Morrow
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  5. R. Cope
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  6. L. G. Hansen
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Correspondence to L. G. Hansen.

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Imsilp, K., Wiedenmann, L., Bordson, G.O. et al. Time- and Tissue-Dependent Polychlorinated Biphenyl Residues in Hairless Mice After Exposure to Polychlorinated Biphenyl-Contaminated Soil. Arch Environ Contam Toxicol 49, 105–118 (2005). https://doi.org/10.1007/s00244-004-0116-y

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  • DOI: https://doi.org/10.1007/s00244-004-0116-y

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