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Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch–Nyhan syndrome

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Abstract

Lesch–Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine–guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. We report a case of renal pelvis calculi which was dissolved within 10 days of urine alkalinization and hydration.

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Authors and Affiliations

  1. Department of Urology, Korea University Hospital, 80, Guro-dong, Guro-ku, Seoul, 152-703, Republic of Korea

    Mi Mi Oh, Byeong Kuk Ham, Seok Ho Kang, Jae Hyun Bae, Je Jong Kim, Duck Ki Yoon & Du Geon Moon

  2. Department of Pediatrics, Korea University Hospital, 80, Guro-dong, Guro-ku, Seoul, 152-703, Republic of Korea

    Ki Hwan Yoo

Authors
  1. Mi Mi Oh
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  2. Byeong Kuk Ham
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  3. Seok Ho Kang
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  4. Jae Hyun Bae
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  5. Je Jong Kim
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  6. Ki Hwan Yoo
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  7. Duck Ki Yoon
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  8. Du Geon Moon
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Correspondence to Du Geon Moon.

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Oh, M.M., Ham, B.K., Kang, S.H. et al. Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch–Nyhan syndrome. Urol Res 39, 417–419 (2011). https://doi.org/10.1007/s00240-011-0364-z

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  • DOI: https://doi.org/10.1007/s00240-011-0364-z

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