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Association between perihematomal perfusion and intracerebral hemorrhage shape

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Abstract

Purpose

The pathophysiological determinants of irregular intracerebral hemorrhage (ICH) shape are unclear. We aimed at characterizing the relationship between perihematomal perfusion and ICH shape.

Methods

A single-center cohort of patients with primary ICH was analyzed. Patients underwent computed tomography perfusion within 6 h from onset. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were calculated in the manually outlined perihematomal low-density region. ICH shape was rated on baseline non-contrast CT following international consensus criteria, and predictors of irregular shape were explored with logistic regression.

Results

A total of 150 patients were included, of whom 66 (44%) had irregular shape. Perihematomal CBF was lower in irregular ICH (median 23 vs 35 mL/100 g/min, p<0.001). CBF<20 mL/100 g/min was independently associated with irregular shape (odds ratio 9.67, 95% CI 2.42–38.69, p=0.001).

Conclusion

Our findings suggest that perihematomal hypoperfusion may contribute to the CT appearance of acute ICH.

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Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy

    Andrea Morotti

  2. Neuroradiology Unit, Department of Radiology, Careggi University Hospital, Florence, Italy

    Giorgio Busto, Elisa Scola & Edoardo Carlesi

  3. Diagnostic Imaging Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

    Francesca Di Pasquale

  4. Section of Neurology, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy

    Ilaria Casetta

  5. Neuroradiology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

    Enrico Fainardi

Authors
  1. Andrea Morotti
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  2. Giorgio Busto
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  3. Elisa Scola
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  4. Edoardo Carlesi
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  5. Francesca Di Pasquale
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  6. Ilaria Casetta
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  7. Enrico Fainardi
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Corresponding author

Correspondence to Andrea Morotti.

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The authors declare that they have no conflict of interest.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Morotti, A., Busto, G., Scola, E. et al. Association between perihematomal perfusion and intracerebral hemorrhage shape. Neuroradiology 63, 1563–1567 (2021). https://doi.org/10.1007/s00234-021-02709-8

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  • DOI: https://doi.org/10.1007/s00234-021-02709-8

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