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Quantitative 1H-MRS reveals metabolic difference between subcategories of malformations of cortical development

  • Paediatric Neuroradiology
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Abstract

Purpose

To figure out the spectra features of malformations of cortical development (MCDs) and the differences between MCDs subcategories.

Methods

Twenty patients and 18 controls were studied. The patients included two subcategories: disorders of migration (DOM) and postmigration (DOPM). Spectra of patients were acquired from both the lesion and the normal-appearing contralateral side (NACS), and they were compared to those of the controls obtained from the frontal lobe.

Results

Compared to the controls, a decreased NAA (P = 0.002) was identified in MCDs. After dividing the MCDs into the DOM and DOPM, we found that NAA reduction was only notable in the DOM (P = 0.007). Moreover, Ins and Cr of the DOPM were higher than those of the controls (P = 0.017 and 0.013) and the DOM (P = 0.027 and 0.001). Compared to the NACS, a decreased NAA (P = 0.042) and an increased Ins (P = 0.039) were identified in the lesion of MCDs. After dividing the MCDs into the DOM and DOPM, we found no significant differences in the DOM, but Ins, Cr, and Glx of the lesion were higher than those of the NACS (P = 0.007, 0.005 and 0.047) in the DOPM. In addition, we found that Cr and Glx correlated positively to the seizure frequency (P = 0.003 and 0.016).

Conclusion

Decreased NAA was the prominent abnormality confirmed in MCDs. Spectra of different MCDs subcategories were different: the DOM was characterized by decreased NAA, while the DOPM was characterized by increased Ins.

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Funding

This work was supported by the Sichuan Provincial Foundation of Science and Technology (grant numbers 2019YFS0428 and 2013SZ0047) and the Foundation of the National Research Center of Geriatrics (grant number Z2018A07).

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Authors and Affiliations

  1. Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Qiaoyue Tan, Xinyue Wan, Weina Wang, Xiaorui Su, Huaiqiang Sun & Simin Zhang

  2. Department of Radiotherapy, West China Hospital of Sichuan University, Chengdu, 610041, China

    Qiaoyue Tan

  3. Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China

    Wenyu Liu

  4. Research Core Facilities, West China Hospital of Sichuan University, Chengdu, 610041, China

    Huaiqiang Sun

  5. Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue lane, Chengdu, 610041, Sichuan, China

    Qiang Yue

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  1. Qiaoyue Tan
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Correspondence to Qiang Yue.

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Institutional Review Board approval was obtained for this study. All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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All subjects or their guardians gave their written informed consent to be enrolled in this study before the MRI examination.

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Tan, Q., Liu, W., Wan, X. et al. Quantitative 1H-MRS reveals metabolic difference between subcategories of malformations of cortical development. Neuroradiology 63, 1539–1548 (2021). https://doi.org/10.1007/s00234-021-02694-y

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