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Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit

  • Diagnostic Neuroradiology
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Abstract

Introduction

The aim of this study was to evaluate whether normal controls and human immunodeficiency virus (HIV) patients with and without planning deficits differ on white matter integrity.

Methods

A total of 34 HIV-positive patients with planning deficits were compared with 13 HIV-positive patients without planning deficits and 19 gender-, age-, and education-matched control subjects. Diffusion tensor imaging (DTI) was performed along 30 noncolinear directions in a 1.5-T scanner. For tract-based spatial statistics analysis, a white matter skeleton was created, and a permutation-based inference with 5000 permutations with a threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The median, radial, and axial diffusivities were also projected onto the mean FA skeleton.

Results

Compared with controls, HIV-positive patients with planning deficits had decreased FA in bilateral anterior thalamic radiations, bilateral inferior fronto-occiptal fasciculi, genu and splenium of the corpus callosum, bilateral superior longitudinal fascicule, and bilateral uncinate fasciculi. Compared to HIV-positive patients without planning deficits, patients with planning deficits had decreased FA in bilateral anterior thalamic radiations, bilateral inferior fronto-occiptal fasciculi, genu of the corpus callosum, bilateral superior longitudinal fascicule, and right uncinate fascicule.

Conclusion

DTI can detect extensive white matter abnormalities in the normal-appearing white matter of HIV-positive patients with planning deficits compared with controls and HIV-positive patients without planning deficits.

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Ethical standards and patient consent

We declare that all human and animals studies have been approved by the Ethical Review Board of the Clementino Fraga Filho University Hospital and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Hospital Universitário Clementino Fraga Filho, Rua Rodolpho Paulo Rocco 255, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, 21941913, Brazil

    Diogo Goulart Corrêa, Nicolle Zimmermann, Thomas M. Doring, Nina Ventura Wilner, Sarah C. B. Leite, Rafael Ferracini Cabral, Rochele Paz Fonseca, Paulo R. V. Bahia & Emerson Leandro Gasparetto

  2. Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro, RJ, Brazil

    Diogo Goulart Corrêa, Thomas M. Doring, Nina Ventura Wilner, Rafael Ferracini Cabral & Emerson Leandro Gasparetto

  3. Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil

    Nicolle Zimmermann & Rochele Paz Fonseca

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  1. Diogo Goulart Corrêa
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  2. Nicolle Zimmermann
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  3. Thomas M. Doring
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  4. Nina Ventura Wilner
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  5. Sarah C. B. Leite
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  8. Paulo R. V. Bahia
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Correspondence to Diogo Goulart Corrêa.

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Corrêa, D.G., Zimmermann, N., Doring, T.M. et al. Diffusion tensor MR imaging of white matter integrity in HIV-positive patients with planning deficit. Neuroradiology 57, 475–482 (2015). https://doi.org/10.1007/s00234-015-1489-5

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  • DOI: https://doi.org/10.1007/s00234-015-1489-5

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