Skip to main content
Log in

Selective embolization of unruptured intracranial aneurysms is associated with low retreatment rate

  • Interventional Neuroradiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

Introduction

To report long-term imaging findings of 101 patients with 129 unruptured intracranial aneurysms (UIA) treated by embolization.

Methods

A retrospective review of our prospectively maintained database identified all patients with an UIA treated by embolization with coils only and with a minimal 12-month imaging follow-up. The clinical charts, procedural data, and angiographic results were reviewed.

Results

Between March 2004 and June 2009, 101 patients with 129 UIA were identified (71 women/30 men, mean age = 51.4 years). Ninety-four aneurysms (73%) were large (10–25 mm), and 35 (27%) were small (<10 mm). Aneurysms mean size was 10.7 mm (median, 9 mm; range 3–22 mm); 87 UIA (67.5%) had a small neck (<4 mm or neck/sac ratio < 0.7), and 42 (32.5%) had a wide neck (≥4 mm or neck/sac ratio ≥ 0.7). Selective coiling with bare/coated coils was performed in 125 cases and four cases, respectively. The balloon-assisted technique was used in 47 cases (36.4%). Only one patient experienced a symptomatic complication (thromboembolism) and kept a slight hemiparesis. Immediate results included 77 complete occlusions (59.7%), 45 neck remnants (34.9%), and 7 incomplete occlusions (5.4%). Mean imaging follow-up of 32 months showed 104 stable occlusions (80.6%), 12 further thrombosis (9.3%), 7 major recanalizations (5.4%), and 6 minor recanalizations (4.7%). Retreatment was required in seven wide-necked and/or large aneurysms including four treated with coated coils. No bleeding occurred during follow-up.

Conclusion

Selective embolization of UIA is associated with stable long-term anatomical results and low retreatment rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. International Study of Unruptured Intracranial Aneurysms Investigators (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362:103–111

    Article  Google Scholar 

  2. Molyneux AJ, Kerr RSC, Yu L-M, Clarke M, Yarnold JA, Sandercock P (2005) International subarachnoid aneurysm trial of neurosurgical clipping versus endovascular coiling of 2,143 patients with ruptured intracranial aneurysms: a randomized comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 366:809–817

    Article  PubMed  Google Scholar 

  3. Origitano TC (2006) Current options in clipping versus coiling of intracranial aneurysms: to clip, to coil, to wait and watch. Neurol Clin North Am 24:765–775

    Google Scholar 

  4. Lubicz B, Balériaux D, Lefranc F, Brotchi J, Bruneau M, Levivier M (2007) Endovascular treatment of intracranial aneurysms as the first therapeutic option: a prospective study over 30 months in a single-centre. J Neuroradiol 34:250–259

    CAS  PubMed  Google Scholar 

  5. Mericle RA, Wakhloo AK, Lopes DK, Lanzino G, Guterman LR, Hopkins LN (1998) Delayed aneurysm regrowth and recanalization after Guglielmi detachable coil treatment. J Neurosurg 89:142–145

    Article  CAS  PubMed  Google Scholar 

  6. Cognard C, Weill A, Spelle L, Piotin M, Castaings L, Rey A, Moret J (1999) Long-term angiographic follow-up of 169 intracranial berry aneurysms occluded with detachable coils. Radiology 212:348–356

    CAS  PubMed  Google Scholar 

  7. Raymond J, Guilbert F, Weill A et al (2003) Long term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 34:1398–1403

    Article  PubMed  Google Scholar 

  8. Murayama Y, Nien YL, Duckwiler G et al (2003) Guglielmi detachable coil embolization of cerebral aneurysms: 11 years' experience. J Neurosurg 98:959–966

    Article  PubMed  Google Scholar 

  9. Sluzewski M, van Rooij WJ, Rinkel GJ et al (2003) Endovascular treatment of ruptured intracranial aneurysms with detachable coils: long-term clinical and serial angiographic results. Radiology 227:720–724

    Article  PubMed  Google Scholar 

  10. Henkes H, Fischer S, Weber W et al (2004) Endovascular coil occlusion of 1,811 intracranial aneurysms: early angiographic and clinical results. Neurosurgery 54:268–285

    Article  PubMed  Google Scholar 

  11. Henkes H, Fischer S, Liebig T et al (2006) Repeated endovascular coil occlusion in 350 of 2,759 intracranial aneurysms: safety and effectiveness aspects. Neurosurgery 58:224–232

    Article  PubMed  Google Scholar 

  12. Grunwald I, Papanagiotou P, Struffert T, Politi M, Krick GG, Reith W (2007) Recanalization after endovascular treatment of intracerebral aneurysms. Neuroradiology 49:41–44

    Article  PubMed  Google Scholar 

  13. Fiehler J, Byrne JV (2009) Factors affecting outcome after endovascular treatment of intracranial aneurysms. Curr Opin Neurol 22:103–108

    Article  PubMed  Google Scholar 

  14. Moret J, Cognard C, Weill A, Castaings L, Rey A (1997) The reconstruction technique in the treatment of wide-neck intracranial aneurysms: long-term angiographic and clinical results. J Neuroradiol 24:30–44

    CAS  PubMed  Google Scholar 

  15. Lubicz B, Leclerc X, Gauvrit JY, Lejeune JP, Pruvo JP (2004) Hyperform remodelling-balloon for endovascular treatment of wide neck intracranial aneurysms. AJNR Am J Neuroradiol 25:1381–1383

    PubMed  Google Scholar 

  16. Lubicz B, Lefranc F, Levivier M et al (2006) Endovascular treatment of intracranial aneurysms with a branch arising from the sac. Am J Neuroradiol 27:142–147

    CAS  PubMed  Google Scholar 

  17. Guglielmi G, Vinuela F, Dion J, Duckwiler G (1991) Electrothrombosis of saccular aneurysms via endovascular approach. Part2: preliminary clinical experience. J Neurosurg 75:8–14

    Article  CAS  PubMed  Google Scholar 

  18. Jennett B, Bond M (1975) Assessment of outcome after severe brain damage. A practical scale. Lancet 1:480–484

    Article  CAS  PubMed  Google Scholar 

  19. Gonzalez N, Murayama Y, Nien YL et al (2004) Treatment of unruptured aneurysms with GDCs: clinical experience with 247 aneurysms. Am J Neuroradiol 25:577–583

    PubMed  Google Scholar 

  20. Gallas S, Drouineau J, Gabrillargues J, Pasco A, Cognard C, Pierot L, Herbreteau D (2008) Feasibility, procedural morbidity and mortality, and long-term follow-up of endovascular treatment of 321 unruptured aneurysms. Am J Neuroradiol 29:63–68

    Article  CAS  PubMed  Google Scholar 

  21. Kataoka K, Taneda M, Asai T, Kinoshita A, Ito M, Kuroda R (1999) Structural fragility and inflammatory response of ruptured cerebral aneurysms: a comparative study between ruptured and unruptured aneurysms. Stroke 30:1396–1401

    CAS  PubMed  Google Scholar 

  22. Piotin M, Spelle L, Mounayer C, Loureiros C, Ghorbani A, Moret J (2009) Intracranial aneurysms coiling with matrix: immediate results in 152 patients and midterm anatomic follow-up from 115 patients. Stroke 40:321–323

    Article  PubMed  Google Scholar 

  23. Lanterna L, Tredici G, Dimitrov B, Biroli F (2004) Treatment of unruptured cerebral aneurysms by embolization with Guglielmi detachable coils: case-fatality, morbidity, and effectiveness in preventing bleeding—a systematic review of the literature. Neurosurgery 55:767–778

    Article  PubMed  Google Scholar 

  24. Sedat J, Chau Y, Mondot L, Vargas J, Szapiro J, Lonjon M (2009) Endovascular occlusion of intracranial wide-necked aneurysms with stenting (Neuroform) and coiling: mid-term and long-term results. Neuroradiology 51:401–409

    Article  PubMed  Google Scholar 

  25. Lubicz B, Bandeira A, Bruneau M, De windt A, Balériaux D, De Witte O (2009) Stenting is improving and stabilizing anatomical results of coiled intracranial aneurysms. Neuroradiology 51:419–425

    Article  PubMed  Google Scholar 

  26. Lylyk P, Miranda C, Ceratto R et al (2009) Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experience. Neurosurgery 64:632–642

    Article  PubMed  Google Scholar 

Download references

Conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Boris Lubicz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bandeira, A., Raphaeli, G., Balériaux, D. et al. Selective embolization of unruptured intracranial aneurysms is associated with low retreatment rate. Neuroradiology 52, 141–146 (2010). https://doi.org/10.1007/s00234-009-0607-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00234-009-0607-7

Keywords

Navigation