Abstract
We have implemented a new diffusion-weighted MRI (DWI) sequence based on the single-shot fast spin-echo technique. We hypothesised that this would add information to conventional MRI for diagnosis of lesions of the cervical spinal cord. DWI was performed using a technique in which echo collection after the application of motion-probing gradients was done in the same manner as in the single-shot fast spin-echo technique. We first imaged six healthy volunteers to demonstrate the cervical spinal cord using the sequence. Then we applied the sequence to 12 patients with cervical myelomalacia due to chronic cord compression. The spinal cord was well seen in all subjects without the distortion associated with echo-planar DWI. In the patients, lesions appeared as areas of low- or isointense signal on DWI. Calculated apparent diffusion coefficients of the lesions (3.30±0.38×10-3 mm2/s) were significantly higher than those of normal volunteers (2.26±0.08×10-3 mm2/s). Increased diffusion in areas of cervical myelomalacia, suggesting irreversible damage, can be detected using this technique.
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Robertson RL, Maier SE, Mulkern RV, Vajapayam S, Robson CD, Barnes PD (2000) MR line-scan diffusion imaging of the spinal cord in children. AJNR 21: 1344–1348
Clark CA, Barker GJ, Tofts PS (1999) Magnetic resonance diffusion imaging of the human cervical spinal cord in vivo. Magn Reson Med 41: 1269–1273
Dietrich O, Herlihy A, Dannels WR, et al (2001) Diffusion-weighted imaging of the spine using radial k-space trajectories. MAGMA 12: 23-31
Hennig J, Nauerth A, Friedburg H (1986) RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 3: 823–833
Alsop DC (1997) Phase insensitive preparation of single-shot RARE: application to diffusion imaging in humans. Magn Reson Med 38: 527–533
McKinnon GC (1993) Ultrafast interleaved gradient-echo-planar imaging on a standard scanner. Magn Reson Med 30: 609–616
Holder CA (2000) MR diffusion imaging of the cervical spine. Magn Reson Imaging Clin N Am 8: 675–86
Schwartz ED, Yezierski RP, Pattany PM, Quencer RM, Weaver RG (1999) Diffusion-weighted MR imaging in a rat model of syringomyelia after excitotoxic spinal cord injury. AJNR 20: 1422–1428
Holder CA, Muthupillai R, Mukundan S Jr, Eastwood JD, Hudgins PA (2000) Diffusion-weighted MR imaging of the normal human spinal cord in vivo. AJNR 21: 1799–1806
Ramanauskas WL, Wilner HI, Metes JJ, Lazo A, Kelly JK (1989) MR imaging of compressive myelomalacia. J Comput Assist Tomogr 13: 399–404
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Tsuchiya, K., Katase, S., Fujikawa, A. et al. Diffusion-weighted MRI of the cervical spinal cord using a single-shot fast spin-echo technique: findings in normal subjects and in myelomalacia. Neuroradiology 45, 90–94 (2003). https://doi.org/10.1007/s00234-002-0898-4
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DOI: https://doi.org/10.1007/s00234-002-0898-4