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Polymorphisms and haplotype analysis of IL-4Rα Q576R and I75V in patients with penicillin allergy

  • Pharmacogenetics
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Background

The interleukin (IL)-4 and IL-4R genes are linked to allergic diseases and atopy and elevated serum IgE levels closely follow the presentation of penicillin allergy. We have evaluated the association between specific immunoglobulin (Ig)E, polymorphisms of IL-4Rα, and penicillin allergy.

Methods

Eight types of specific IgE to penicillins were detected with the radioallergosorbent test (RAST) in 242 patients with penicillin allergy and 220 control subjects. Polymorphisms of IL-4Rα Q576R and IL-4Rα I75V were genotyped by PCR–restriction fragment length polymorphism (RFLP). The polymorphisms and haplotype of IL-4Rα Q576R and I75V were analyzed.

Results

For IL-4Rα Q576R, the frequency of the AA genotype was higher in patients with penicillin allergy (76 vs. 64%, P = 0.005). The A allele occurred more frequently in the penicillin-allergic patients than in the controls (87 vs. 80%, P = 0.003). For IL-4Rα I75V, the AA genotype was more likely to be detected in the urticaria group than in the control group (32 vs. 19%, P = 0.049). Haplotype analysis revealed that Q576/I75 was more frequently found in patients with penicillin allergy than in controls (42 vs. 35%, P = 0.037).

Conclusions

The IL4Rα Q576 allele is related to penicillin allergy, and the IL-4Rα I75 allele is associated with the symptom of urticaria. The Q576/I75 haplotype may be related with an allergy to penicillin.

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Correspondence to Hai-Ling Qiao.

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Huang, CZ., Yang, J., Qiao, HL. et al. Polymorphisms and haplotype analysis of IL-4Rα Q576R and I75V in patients with penicillin allergy. Eur J Clin Pharmacol 65, 895–902 (2009). https://doi.org/10.1007/s00228-009-0659-y

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  • DOI: https://doi.org/10.1007/s00228-009-0659-y

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