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Comparison of intravenous dexketoprofen and dipyrone in acute renal colic

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Abstract

Objective

The aim of this study was to assess the efficacy and safety of a single intravenous (i.v.) bolus of dexketoprofen trometamol compared with an i.v. infusion of dipyrone in patients with moderate to severe pain due to renal colic.

Methods

A total of 308 patients with renal colic and visual analog scale (VAS) score ≥40 mm participated in a multicenter, randomized, double blind, double-dummy, parallel, and active-controlled study and were randomized to dexketoprofen 25 mg (n = 101), dexketoprofen 50 mg (n = 104), and dipyrone 2 g (n = 103).

Results

Mean [± standard deviation (SD)] total pain relief (TOTPAR) scores were similar in the dexketoprofen 50 mg (15.3 ± 8.6) and dipyrone (15.5 ± 8.6) and slighly higher than in dexketoprofen 25 mg (13.5 ± 8.6), although significant differences were not achieved. In the same way, patients in the dexketoprofen 50 mg and dipyrone groups showed higher scores in the sum of pain intensity differences (SPID) and the sum of analogue pain intensity differences (SAPID) than patients in the dexketoprofen 25 mg group, reaching statistical significance in comparison with dexketoprofen 25 mg and dipyrone for SPID and SAPID (p < 0.05). The time–effect course for pain intensity differences and pain relief showed significantly higher values for both doses of dexketoprofen during the first 30 min after drug administration (p < 0.05). Dexketoprofen 50 mg and dipyrone groups had 66% and 70%, respectively, of patients with at least 50% of maximum obtainable TOTPAR in comparison with 56% in the dexketoprofen 25 mg group. The study medications were well tolerated.

Conclusions

Dexketoprofen 50 mg administered as a single i.v. bolus was effective for the relief of moderate to severe pain in patients with renal colic, with a good safety profile and efficacy similar to i.v. dipyrone 2 g. Dexketoprofen produced analgesia that was faster in onset.

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Acknowledgments

This study was financially supported by a grant from the Menarini Group. The authors have no conflicts of interest directly relevant to the content of this study. The authors thank Marta Pulido MD for editing the manuscript and editorial assistance, and Silvia Garrido for the technical support.

Author information

Authors and Affiliations

  1. Emergency Department, Hospital Universitario Dr. Peset, Valencia, Spain

    Juan Sánchez-Carpena

  2. Emergency Department, Complejo Hospitalario Cristal Piñor, Ourense, Spain

    Fermín Domínguez-Hervella

  3. Emergency Department, Consorci Sanitari Integral, Hospital General de l’Hospitalet de Llobregat, Barcelona, Spain

    Ignasi García

  4. Emergency Department, Corporació Sanitària Parc Taulí, Hospital de Sabadell, Sabadell, Barcelona, Spain

    Emili Gene

  5. Emergency Department, Hospital Clínico Universitario, Santiago de Compostela, Spain

    Rosendo Bugarín

  6. Emergency Department, Policlínica de Vigo, S.A, Pontevedra, Spain

    Angel Martín

  7. Emergency Department, Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain

    Santiago Tomás-Vecina

  8. Emergency Department, Consorci Sanitari de Terrassa, Terrassa, Barcelona, Spain

    Dolors García

  9. Emergency Department, Hospital General Universitario Morales Messeguer, Murcia, Spain

    José Antonio Serrano

  10. Emergency Department, Hospital General Universitario de Guadalajara, Guadalajara, Spain

    Antonio Roman

  11. Emergency Department, Hospital de El Escorial, El Escorial, Madrid, Spain

    Miguel Mariné

  12. Emergency Department, Hospital de Montecelo, Pontevedra, Spain

    María Luisa Mosteiro

Authors
  1. Juan Sánchez-Carpena
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  2. Fermín Domínguez-Hervella
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  3. Ignasi García
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  4. Emili Gene
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  5. Rosendo Bugarín
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  6. Angel Martín
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  7. Santiago Tomás-Vecina
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  8. Dolors García
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  9. José Antonio Serrano
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  10. Antonio Roman
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  11. Miguel Mariné
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  12. María Luisa Mosteiro
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Consortia

the Dexketoprofen Renal Colic Study Group

Corresponding author

Correspondence to Juan Sánchez-Carpena.

Additional information

Dexketoprofen Renal Colic Study Group: S. Tomás Vecina, Hospital Mútua de Terrassa, Barcelona; Ma L. Recuero Sánchez, Hospital del Insalud de Mérida, Badajoz; R. Bugarín González, Hospital Clínico Universitario, Santiago de Compostela, E. Gene Tous, Corporació Sanitària Parc Taulí, Sabadell, Barcelona; JA. Mota Gracia, Hospital Rafael Méndez, Murcia; A. Román Jasanada, Hospital General Universitario de Guadalajara, Guadalajara; Sonia González, Fundación Hospital Alcorcón, Alcorcón, Madrid; D. García Alonso, Consorci Sanitari de Terrassa, Terrassa, Barcelona; L García González, Consorci Sanitari Integral, Hospital General de l’Hospitalet de Llobregat, Barcelona; J. Sánchez Carpena, Hospital Universitario Dr. Peset, Valencia; M. Mariné Blanco, Hospital de El Escorial, El Escorial, Madrid; F, Roqueta Egea, Fundació Althaia — Xarxa Assistencial de Manresa, Manresa, Barcelona; J. A. Serrano Martínez, Hospital General Universitario Morales Messeguer, Murcia; G. Ferrán Martínez, Hospital General de Castellón, Castellón; A. Martín Joven, Policlínica de Vigo, S.A, Pontevedra; M.L. Mosteiro Álvarez, Hospital de Montecelo, Pontevedra; and F. Domínguez Hervella, Complejo Hospitalario Cristal Piñor, Ourense.

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Sánchez-Carpena, J., Domínguez-Hervella, F., García, I. et al. Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. Eur J Clin Pharmacol 63, 751–760 (2007). https://doi.org/10.1007/s00228-007-0322-4

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  • DOI: https://doi.org/10.1007/s00228-007-0322-4

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