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Effects of acute trigeminal nerve stimulation on rest EEG activity in healthy adults

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Abstract

Trigeminal nerve stimulation (TNS) is a non-invasive neuromodulation method which is increasingly used for its beneficial effects on symptoms of several neuropsychiatric disorders such as drug-resistant epilepsy. Sites and mechanisms of its action are still unknown. The present study was aimed at investigating the physiological effects of acute TNS on rest electroencephalographic (EEG) activity. EEG was recorded with a 19-channel EEG system from 18 healthy adults who underwent 20 min of sham- and real-TNS (cycles of 30 s ON and 30 s OFF) in two separate sessions. EEG was continuously acquired in the 10-min preceding TNS, during TNS in the “OFF” period and throughout 10 min after TNS. Mean frequency, total power over the 0.5–48 Hz frequency range and absolute power for delta, theta, alpha, beta and gamma bands were analyzed by a discrete Fast Fourier Transform algorithm. Interhemispheric and intrahemispheric coherences were also analyzed for each band at different time points. Intra- and interhemispheric coherences were significantly reduced for the beta frequencies only during real-TNS (p = 0.002 and p = 0.006, respectively). No TNS effect on the power spectra of any band was detected. A trend of increase in the mean EEG frequency total power during real-TNS (p = 0.03) and of decrease in interhemispheric gamma coherence after real-TNS (p = 0.01) was observed. Acute TNS may induce a spatially diffuse desynchronization of fast EEG rhythms in healthy adults, this desynchronization may underpin the antiepileptic effect of TNS described by clinical studies.

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Author notes

  1. F. Ginatempo and F. De Carli contributed equally to this work.

Authors and Affiliations

  1. Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100, Sassari, Italy

    Francesca Ginatempo, Beniamina Mercante & Franca Deriu

  2. Genoa Section, Institute of Bioimaging and Molecular Physiology, National Research Council, Genoa, Italy

    Fabrizio De Carli

  3. Neurology Unit, «A. Segni» Hospital, ASL n. 1, Sassari, Italy

    Sara Todesco

  4. Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy

    Gian Pietro Sechi

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  1. Francesca Ginatempo
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  2. Fabrizio De Carli
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  3. Sara Todesco
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  4. Beniamina Mercante
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Correspondence to Franca Deriu.

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Ginatempo, F., De Carli, F., Todesco, S. et al. Effects of acute trigeminal nerve stimulation on rest EEG activity in healthy adults. Exp Brain Res 236, 2839–2845 (2018). https://doi.org/10.1007/s00221-018-5338-8

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  • DOI: https://doi.org/10.1007/s00221-018-5338-8

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