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Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury

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Abstract

Hyperbaric oxygen (HBO) therapy helps alleviate secondary injury following brain trauma [traumatic brain injury (TBI)], although the mechanisms remain unclear. In this study, we assessed recovery of post-TBI spatial learning and memory in rats using the Morris water maze (MWM) and measured changes in apparent diffusion coefficient in the hippocampus by diffusion-weighted imaging (DWI) to evaluate possible therapeutic effects of HBO on TBI-associated brain edema. DWIs were obtained 8, 24, 48 h, 7 days, and 14 days post-TBI. Daily HBO therapy significantly improved post-TBI MWM performance and reduced edema in the ipsilateral hippocampus, suggesting that the therapeutic efficacy of HBO is mediated, at least in part, by a reduction in brain edema.

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Abbreviations

TBI:

Traumatic brain injury

MWM:

Morris water maze

DWI:

Diffusion-weighted imaging

ADC:

Apparent diffusion coefficient

HBO:

Hyperbaric oxygen

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Acknowledgments

We are thankful for the excellent technical assistance of Zhijun Zhang and Yulin Dong. This study was supported by the Science and Technology Plan Projects of Nantong (Grant No. HS13967TDFY0348).

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China

    Su Liu, Aisong Guo & Guangyu Shen

  2. Department of Pathology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China

    Ying Liu

  3. Department of Imaging, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China

    Xiubing Wang

  4. Department of Rehabilitation Medicine, Wuxi People’s Hospital, 299 Qingyang Road, Wuxi, 214023, China

    Shukun Deng

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  1. Su Liu
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  2. Ying Liu
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  3. Shukun Deng
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  4. Aisong Guo
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  5. Xiubing Wang
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  6. Guangyu Shen
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Correspondence to Guangyu Shen.

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Liu, S., Liu, Y., Deng, S. et al. Beneficial effects of hyperbaric oxygen on edema in rat hippocampus following traumatic brain injury. Exp Brain Res 233, 3359–3365 (2015). https://doi.org/10.1007/s00221-015-4405-7

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  • DOI: https://doi.org/10.1007/s00221-015-4405-7

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