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The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis

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Abstract

The aim of this study was to examine whether single-pulse transcranial magnetic stimulation (spTMS) affects the pattern of corticospinal activity once voluntary drive has been restored after spTMS-induced EMG silence. We used fractal dimension (FD) to explore the ‘complexity’ of the electromyography (EMG) signal, and median frequency of the spectra (MDF) to examine changes in EMG spectral characteristics. FD and MDF of the raw EMG epochs immediately before were compared with those obtained from epochs after the EMG silence. Changes in FD and MDF after spTMS were examined with three levels of muscle contraction corresponding to weak (20–40 %), moderate (40–60 %) and strong (60–80 % of maximal voluntary contraction) and three intensities of stimulation set at 10, 20 and 30 % above the resting motor threshold. FD was calculated using the Higuchi fractal dimension algorithm. Finally, to discern the origin of FD changes between the CNS and muscle, we compared the effects of spTMS with the effects of peripheral nerve stimulation (PNS) on FD and MDF. The results show that spTMS induced significant decrease in both FD and MDF of EMG signal after stimulation. PNS did not have any significant effects on FD nor MDF. Changes in TMS intensity did not have any significant effect on FD or MDF after stimulation nor had the strength of muscle contraction. However, increase in contraction strength decreased FD before stimulation but only between weak and moderate contraction. The results suggest that the effects of spTMS on corticospinal activity, underlying voluntary motor output, outlast the TMS stimulus. It appears that the complexity of the EMG signal is reduced after spTMS, suggesting that TMS alters the dynamics of the ongoing corticospinal activity most likely temporarily synchronizing the neural network activity. Further studies are needed to confirm whether observed changes after TMS occur at the cortical level.

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Acknowledgments

The research was partly supported by Ministry of Education and Science of Serbia projects 175090, 175012, III-41007 and III-43011 and FMHS UAE University Grant.

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Authors and Affiliations

  1. Biomedical Center, Torlak Institute, Belgrade, Serbia

    M. Cukic

  2. Department for Computing and Control Engineering, Faculty of Technical Sciences, University Novi Sad, Novi Sad, Serbia

    M. Cukic & N. Jorgovanovic

  3. Department of Physiology, FMHS, College of Medicine and Health Sciences, UAE University, Al Ain, UAE

    J. Oommen & M. Ljubisavljevic

  4. Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbia

    D. Mutavdzic

  5. Institute for Medical Research, University of Belgrade, Belgrade, Serbia

    M. Ljubisavljevic

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  1. M. Cukic
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Correspondence to M. Ljubisavljevic.

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Cukic, M., Oommen, J., Mutavdzic, D. et al. The effect of single-pulse transcranial magnetic stimulation and peripheral nerve stimulation on complexity of EMG signal: fractal analysis. Exp Brain Res 228, 97–104 (2013). https://doi.org/10.1007/s00221-013-3541-1

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