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The auditory startle response in post-traumatic stress disorder

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Abstract

Post-traumatic stress disorder (PTSD) patients are considered to have excessive EMG responses in the orbicularis oculi (OO) muscle and excessive autonomic responses to startling stimuli. The aim of the present study was to gain more insight into the pattern of the generalized auditory startle reflex (ASR). Reflex EMG responses to auditory startling stimuli in seven muscles rather than the EMG response of the OO alone as well as the psychogalvanic reflex (PGR) were studied in PTSD patients and healthy controls. Ten subjects with chronic PTSD (>3 months) and a history of excessive startling and 11 healthy controls were included. Latency, amplitude and duration of the EMG responses and the amplitude of the PGR to 10 auditory stimuli of 110 dB SPL were investigated in seven left-sided muscles. The size of the startle reflex, defined by the number of muscles activated by the acoustic stimulus and by the amplitude of the EMG response of the OO muscle as well, did not differ significantly between patients and controls. Median latencies of activity in the sternocleidomastoid (SC) (patients 80 ms; controls 54 ms) and the deltoid (DE) muscles (patients 113 ms; controls 69 ms) were prolonged significantly in PTSD compared to controls (P<0.05). In the OO muscle, a late response (median latency in patients 308 ms; in controls 522 ms), probably the orienting reflex, was more frequently present in patients (56%) than in controls (12%). In patients, the mean PGR was enlarged compared to controls (P<0.05). The size of the ASR response is not enlarged in PTSD patients. EMG latencies in the PTSD patients are prolonged in SC and DE muscles. The presence of a late response in the OO muscle discriminates between groups of PTSD patients with a history of startling and healthy controls. In addition, the autonomic response, i.e. the enlarged amplitude of the PGR can discriminate between these groups.

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References

  • Adamec R, Bartoszyk GD, Burton P (2004) Effects of systemic injections of Vilazodone, a selective serotonin reuptake inhibitor and serotonin 1A receptor agonist, on anxiety induced by predator stress in rats. Eur J Pharmacol 504:65–77

    Article  PubMed  CAS  Google Scholar 

  • Baas JM, Grillon C, Bocker KB, Brack AA, Morgan CA, Kenemans JL, Verbaten MN (2002) Benzodiazepines have no effect on fear-potentiated startle in humans. Psychopharmacology (Berl) 161:233–247

    Article  CAS  Google Scholar 

  • Biosemi, Amsterdam. http://www.biosemi.com/active electrode.htm, http://www.biosemi.com/activetwo_full_specs.htm

  • Brown P, Rothwell JC, Thompson PD, Britton TC, Day BL, Marsden CD (1991a) New observations on the normal auditory startle reflex in man. Brain 114(Pt 4):1891–1902

    Article  Google Scholar 

  • Brown P, Day BL, Rothwell JC, Thompson PD, Marsden CD (1991b) The effect of posture on the normal and pathological auditory startle reflex. J Neurol Neurosurg Psychiatry 54:892–897

    Article  CAS  Google Scholar 

  • Carlier IV, Lamberts RD, Van Uchelen AJ, Gersons BP (1998) Clinical utility of a brief diagnostic test for posttraumatic stress disorder. Psychosom Med 60:42–47

    PubMed  CAS  Google Scholar 

  • Carpenter MG, Allum JH, Honegger F, Adkin AL, Bloem BR (2004) Postural abnormalities to multidirectional stance perturbations in Parkinson’s disease. J Neurol Neurosurg Psychiatry 75:1245–1254

    Article  PubMed  CAS  Google Scholar 

  • Clark CR, Geffen GM, Geffen LB (1989) Catecholamines and the covert orientation of attention in humans. Neuropsychologia 27:131–139

    Article  PubMed  CAS  Google Scholar 

  • Commissaris RL, Fomum EA, Leavell BJ (2005) Effects of buspirone and alprazolam treatment on the startle-potentiated startle response. Depress Anxiety 19:146–151

    Article  CAS  Google Scholar 

  • Gogan P (1970) The startle and orienting reactions in man. A study of their characteristics and habituation. Brain Res 18:117–135

    Article  PubMed  CAS  Google Scholar 

  • Grillon C, Morgan CA, Southwick SM, Davis M, Charney DS (1996) Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res 64:169–178

    Article  PubMed  CAS  Google Scholar 

  • Kofler M, Muller J, Reggiani L, Valls-Sole J (2001a) Influence of age on auditory startle responses in humans. Neurosci Lett 307:65–68

    Article  CAS  Google Scholar 

  • Kofler M, Muller J, Reggiani L, Valls-Sole J (2001b) Influence of gender on auditory startle responses. Brain Res 921:206–210

    Article  CAS  Google Scholar 

  • Kofler M, Muller J, Wenning GK, Reggiani L, Hollosi P, Bosch S, Ransmayr G , Valls-Sole J, Poewe W (2001c) The auditory startle reaction in parkinsonian disorders. Mov Disord 16:62–71

    Article  CAS  Google Scholar 

  • Metting v Rijn A, Peper A, Grimbergen CA (1990) High-quality recording of bioelectric events. Part 1. Interference reduction, theory and practice. Med Biol Eng Comput 28:389–397

    Article  PubMed  Google Scholar 

  • Metting v Rijn A, Peper A, Grimbergen CA (1991) High-quality recording of bioelectric events. Part 2. Low-noise, low-power multichannel amplifier design. Med Biol Eng Comput 29:433–440

    Article  PubMed  Google Scholar 

  • Metzger LJ, Orr SP, Berry NJ, Ahern CE, Lasko NB, Pitman RK (1999) Physiologic reactivity to startling tones in women with posttraumatic stress disorder. J Abnorm Psychol 108:347–352

    Article  PubMed  CAS  Google Scholar 

  • Muller J, Kofler M, Wenning GK, Seppi K, Valls-Sole J, Poewe W (2003) Auditory startle response in cervical dystonia. Mov Disord 18:1522–6

    Article  PubMed  Google Scholar 

  • Naudin B, Canu S, Costentin J (1990) Effects of various direct or indirect dopamine agonists on the latency of the acoustic startle response in rats. J Neural Transm Gen Sect 82:43–53

    Article  PubMed  CAS  Google Scholar 

  • Orr SP, Roth WT (2000) Psychophysiological assessment: clinical applications for PTSD. J Affect Disord 61:225–240

    Article  PubMed  CAS  Google Scholar 

  • Orr SP, Lasko NB, Metzger LJ, Pitman RK (1997) Physiologic responses to non-startling tones in Vietnam veterans with post-traumatic stress disorder. Psychiatry Res 73:103–107

    Article  PubMed  CAS  Google Scholar 

  • Orr SP, Metzger LJ, Pitman RK (2002) Psychophysiology of post-traumatic stress disorder. Psychiatr Clin North Am 25:271–293

    Article  PubMed  Google Scholar 

  • Shalev AY (2004) What is posttraumatic stress disorder? J Clin Psychiatry 62 (Suppl 17):4–10

    Google Scholar 

  • Shalev AY, Orr SP, Peri T, Schreiber S, Pitman RK (1992) Physiologic responses to loud tones in Israeli patients with posttraumatic stress disorder. Arch Gen Psychiatry 49:870–875

    PubMed  CAS  Google Scholar 

  • Shalev AY, Peri T, Orr SP, Bonne O, Pitman RK (1997) Auditory startle responses in help-seeking trauma survivors. Psychiatry Res 69:1–7

    Article  PubMed  CAS  Google Scholar 

  • Shalev AY, Peri T, Brandes D, Freedman S, Orr SP, Pitman RK (2000) Auditory startle response in trauma survivors with posttraumatic stress disorder: a prospective study. Am J Psychiatry 157:255–261

    Article  PubMed  CAS  Google Scholar 

  • Southwick SM, Morgan CA, Bremner AD, Grillon CG, Krystal JH, Nagy LM, Charney DS (1997) Noradrenergic alterations in posttraumatic stress disorder. Ann NY Acad Sci 821:125–141

    Article  PubMed  CAS  Google Scholar 

  • Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS (1999) Neurotransmitter alterations in PTSD: catecholamines and serotonin. Semin Clin Neuropsychiatry 4:242–248

    PubMed  CAS  Google Scholar 

  • Spivak B, Vered Y, Graff E, Blum I, Mester R, Weizman A (1999) Low platelet-poor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder. Biol Psychiatry 45:840–845

    Article  PubMed  CAS  Google Scholar 

  • Svensson L (1985) Effects of 8-OH-DPAT, lisuride and some ergot-related compounds on the acoustic startle response in the rat. Psychopharmacology (Berl) 85:469–475

    Article  CAS  Google Scholar 

  • Tijssen MA, Voorkamp LM, Padberg GW, van Dijk JG (1997) Startle responses in hereditary hyperekplexia. Arch Neurol 54:388–393

    PubMed  CAS  Google Scholar 

  • Voshaar RC, Verkes RJ, van Luijtelaar GL, Edelbroek PM, Zitman FG (2005) Effects of additional oxazepam in long-term users of oxazepam. J Clin Psychopharmacol 25:42–50

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Departments of Neurology H2-222 and Clinical Neurophysiology, Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands

    S. E. Siegelaar, L. J. Bour, D. Veelo, G. van Bruggen, J. H. T. M. Koelman & M. A. J. Tijssen

  2. Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands

    M. Olff, G. J. de Vries, S. Raabe & C. Cupido

  3. Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands

    A. H. Zwinderman

Authors
  1. S. E. Siegelaar
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  2. M. Olff
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  3. L. J. Bour
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  4. D. Veelo
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  5. A. H. Zwinderman
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  6. G. van Bruggen
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  7. G. J. de Vries
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  8. S. Raabe
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  9. C. Cupido
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  10. J. H. T. M. Koelman
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  11. M. A. J. Tijssen
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Correspondence to M. A. J. Tijssen.

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Siegelaar, S., Olff, M., Bour, L. et al. The auditory startle response in post-traumatic stress disorder. Exp Brain Res 174, 1–6 (2006). https://doi.org/10.1007/s00221-006-0413-y

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  • DOI: https://doi.org/10.1007/s00221-006-0413-y

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