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Analysis of illicit drugs by nonaqueous capillary electrophoresis and electrochemical detection

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Abstract

Nonaqueous capillary electrophoresis (NACE) was applied to the determination of illicit drugs. The complete separation of amphetamine, methamphetamine, 3,4-methylene dioxy amphetamine (MDA), 3,4-methylene dioxy methamphetamine (MDMA), mescaline, cocaine and benzoylecgonine was obtained using an acetonitrile based buffer solution containing 10 mM sodium acetate and 1 M acetic acid. Electrochemical detection using a Pt microdisk electrode set to a potential of +1.8 V was found to be selective for MDA, MDMA and mescaline. The detection limits for these compounds were in the low ng/mL range which is between 2 and 3 orders of magnitude lower compared to UV-detection.

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Authors and Affiliations

  1. University of Kansas, Department of Chemistry, Lawrence, KS. 66045, USA, , , , , , US

    Ulli Backofen & C. E. Lunte

  2. Universität Leipzig, Institut für Analytische Chemie, Linnéstrasse 3, 04103 Leipzig, Germany, , , , , , DE

    Frank-Michael Matysik

  3. Forschungszentrum Karlsruhe, Institut für Instrumentelle Analytik, 76344 Eggenstein-Leopoldshafen, Germany, , , , , , DE

    Werner Hoffmann

Authors
  1. Ulli Backofen
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  2. Frank-Michael Matysik
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  3. Werner Hoffmann
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  4. C. E. Lunte
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Received: 30 December 1999 / Revised: 10 February / Accepted: 15 February 2000

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Backofen, U., Matysik, FM., Hoffmann, W. et al. Analysis of illicit drugs by nonaqueous capillary electrophoresis and electrochemical detection. Fresenius J Anal Chem 367, 359–363 (2000). https://doi.org/10.1007/s002160000371

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  • DOI: https://doi.org/10.1007/s002160000371

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