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Recent methodological advances in MALDI mass spectrometry

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Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used for characterization of large, thermally labile biomolecules. Advantages of this analytical technique are high sensitivity, robustness, high-throughput capacity, and applicability to a wide range of compound classes. For some years, MALDI-MS has also been increasingly used for mass spectrometric imaging as well as in other areas of clinical research. Recently, several new concepts have been presented that have the potential to further advance the performance characteristics of MALDI. Among these innovations are novel matrices with low proton affinities for particularly efficient protonation of analyte molecules, use of wavelength-tunable lasers to achieve optimum excitation conditions, and use of liquid matrices for improved quantification. Instrumental modifications have also made possible MALDI-MS imaging with cellular resolution as well as an efficient generation of multiply charged MALDI ions by use of heated vacuum interfaces. This article reviews these recent innovations and gives the author’s personal outlook of possible future developments.

Figure published in Cramer, RC, Dreisewerd, K. (2007) UV Matrix‐Assisted Laser Desorption/Ionization: Principles, Instrumentation, and Applications. In: M. Gross (Ed.): Encyclopedia of Mass Spectrometry, Vol. 6, pp 646‐661, Elsevier, Oxford

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Acknowledgments

The author thanks the members of his workgroup, especially Thorsten W. Jaskolla (TWJ) and Jens Soltwisch, for numerous helpful discussions. Financial support by the German Science Foundation (grants DR416/8-1, DR416/8-2, DR416/9-1, and DR16/10-1 to KD, and JA2127/1-1 to TWJ) and the Interdisciplinary Center for Clinical Research (IZKF) of the Münster University Medical School (grant Z03) is gratefully acknowledged.

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  1. Institute for Hygiene, Biomedical Mass Spectrometry, University of Münster, Robert-Koch-Str. 41, 48149, Münster, Germany

    Klaus Dreisewerd

  2. Interdisciplinary Center for Clinical Research (IZKF) Münster, University of Münster, Domagkstr. 3, 48149, Münster, Germany

    Klaus Dreisewerd

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Dreisewerd, K. Recent methodological advances in MALDI mass spectrometry. Anal Bioanal Chem 406, 2261–2278 (2014). https://doi.org/10.1007/s00216-014-7646-6

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