Skip to main content
SpringerLink
Log in

Potentiometric propranolol-selective sensor based on molecularly imprinted polymer

  • Original Paper
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

A novel potentiometric sensor based on molecularly imprinted polymer (MIP) for propranolol, an adrenergic-blocking drug, was designed. The influence of molecularly imprinted polymer particle content and sodium tetraphenylborate additives in polyvinylchloride membrane was shown. The electrodes show near-Nernstian responses down to 10−4–10−5 M propranolol concentration. The potentiometric response of MIP-based sensor for propranolol in mixed nonaqueous medium was shown at first. Sensor selectivity relative to various inorganic cations, atenolol and metoprolol, was reported. Direct potentiometry was used to determine propranolol in aqueous modeling solutions and pharmaceutical preparations with good results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Holthoff E, Bright F (2007) Anal Chim Acta 594:147–161

    Article  CAS  Google Scholar 

  2. Prasada Rao T, Kala R (2008) Talanta 76:485–496

    Article  CAS  Google Scholar 

  3. Wulff G (2002) Chem Rev 102:1–28

    Article  CAS  Google Scholar 

  4. Ye L, Mosbach K (2008) Chem Mater 20:859–869

    Article  CAS  Google Scholar 

  5. Liang R, Zhang R, Qin W (2009) Sensors Actuators B Chem 141:544–550

    Article  Google Scholar 

  6. Prasad K, Prathish KP, Mary Gladis J, Naidu GRK, Prasada Rao T (2007) Sensors Actuators B Chem 123:65–70

    Article  Google Scholar 

  7. Alizadeh T, Akhoundian M (2010) Electrochim Acta 55:3477–3485

    Article  CAS  Google Scholar 

  8. Prathish KP, Prasad K, Prasada Rao T, Suryanarayana MVS (2007) Talanta 71:1976–1980

    Article  CAS  Google Scholar 

  9. Moreira FTC, Kamel AH, Guerreiro JRL, Sales MGF (2010) Biosens Bioelectron 26:566–574

    Article  CAS  Google Scholar 

  10. Rebelo TSCR, Almeida SAA, Guerreiro JRL, Montenegro MCBSM, Sales MGF (2011) Microchem J 98:21–28

    Article  CAS  Google Scholar 

  11. Sadeghi S, Fathi F, Abbasifar (2007) J Sensors Actuators B Chem 122:158–164

    Article  Google Scholar 

  12. Guerreiro JRL, Freitas V, Sales MGF (2011) Microchem J 97:173–181

    Article  CAS  Google Scholar 

  13. Metilda P, Prasad K, Kala R, Gladis JM, Prasada Rao T, Naidu GRK (2007) Anal Chim Acta 582:147–153

    Article  CAS  Google Scholar 

  14. Vishnuvardhan V, Prathish KP, Naidu GRK, Prasada Rao T (2007) Electrochim Acta 52:6922–6928

    Article  CAS  Google Scholar 

  15. Prasad K, Kala R, Prasada Rao T, Naidu GRK (2006) Anal Chim Acta 566:69–74

    Article  CAS  Google Scholar 

  16. Javanbakht M, Fard SE, Mohammadi A, Abdouss M, Ganjali MR, Norouzi P, Safaraliee L (2008) Anal Chim Acta 612:65–74

    Article  CAS  Google Scholar 

  17. D’Agostino G, Alberti G, Biesuz R, Pesavento M (2006) Biosens Bioelectron 22:145–152

    Article  Google Scholar 

  18. Huang J, Xing X, Zhang X, He X, Lin Q, Lian W, Zhu H (2011) Food Res Int 44:276–281

    Article  CAS  Google Scholar 

  19. Wang Y, Zhang Z, Jain V, Yi J, Mueller S, Sokolov J, Liu Z, Levon K, Rigas B, Rafailovich MH (2010) Sensors Actuators B Chem 146:381–387

    Article  Google Scholar 

  20. Wang Y, Zhou Y, Sokolov J, Rigas B, Levon K, Rafailovich M (2008) Biosens Bioelectron 24:162–166

    Article  Google Scholar 

  21. Ali SMU, Nur O, Willander M, Danielsson B (2010) Sensors Actuators B Chem 145:869–874

    Article  Google Scholar 

  22. Fulati A, Ali SMU, Asif MH, Alvi NH, Willander M, Brännmark C, Stralfors P, Börjesson SI, Elinder F, Danielsson B (2010) Sensors Actuators B Chem 150:673–680

    Article  Google Scholar 

  23. Zhou Y, Yu B, Levon K (2005) Biosens Bioelectron 20:1851–1855

    Article  CAS  Google Scholar 

  24. Chen X, Yang Z, Si S (2009) J Electroanal Chem 635:1–6

    Article  CAS  Google Scholar 

  25. Şahin M, Özcan L, Usta B, Şahin Y (2009) Biosens Bioelectron 24:3492–3497

    Article  Google Scholar 

  26. Sabah S, Aghamohammadi M, Alizadeh N (2006) Sensors Actuators B Chem 114:489–496

    Article  Google Scholar 

  27. Zanganeh AR, Amini MK (2007) Electrochim Acta 52:3822–3830

    Article  CAS  Google Scholar 

  28. Bendikov TA, Kim J, Harmon TC (2005) Sensors Actuators B Chem 106:512–517

    Article  Google Scholar 

  29. Zanganeh AR, Amini MK (2008) Sensors Actuators B Chem 135:358–365

    Article  Google Scholar 

  30. Riskin M et al (2010) Chem Eur J 16:7114–7120

    CAS  Google Scholar 

  31. Li C, Wang C, Guan B, Zhang Y, Hu S (2005) Sensors Actuators B Chem 107:411–417

    Article  Google Scholar 

  32. Fernández-Sánchez JF, Carretero AS, Cruces-Blanco C et al (2003) J Pharm Biomed Anal 31:859–865

    Article  Google Scholar 

  33. Pulgarin JAM, Molina AA, Lopez PF (1998) Anal Chim Acta 370:9–18

    Article  Google Scholar 

  34. The 2004 prohibited list, World Anti-Doping Code, Nov. 25 (2003)

  35. Aboul-Enein HY, Sun XX (2000) Analusis 28:855–858

    Article  CAS  Google Scholar 

  36. Mullett WM, Martín P, Pawliszyn J (2001) Anal Chem 73:2383

    Article  CAS  Google Scholar 

  37. Hassan S, Amer M, Abd E-F, El-Kosasy A (1998) Anal Chim Acta 363:81–87

    Article  CAS  Google Scholar 

  38. Stefan R, Baiulescu G, Aboul-Enein H (1997) Crit Rev Anal Chem 24:307–321

    Article  Google Scholar 

  39. Chmilenko FA, Korobova IV, Gurtovaya OV, Chmilenko TS (2009) Talanta 78:1259–1265

    Article  CAS  Google Scholar 

  40. Chmilenko FA, Korobova IV, Gurtovaya OV (2008) J Anal Chem 63:590–595

    Article  CAS  Google Scholar 

  41. Yoshimatsu K, Reimhult K, Krozer A, Mosbach K, Sode K, Ye L (2007) Anal Chim Acta 584:112–121

    Article  CAS  Google Scholar 

  42. Singh AK, Saxena P (2005) Talanta 66:993–998

    Article  CAS  Google Scholar 

  43. Barbosa J, Burt S, Sanz-Nebot V (1994) Talanta 41:825–831

    Article  CAS  Google Scholar 

  44. Janata J (2010) Principles of chemical sensors. Springer, Heidelberg

    Google Scholar 

  45. Nezamzadeh-Ejhieh A, Badri AJ (2011) Electroanal Chem 660:71–79

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We gratefully acknowledge the financial support from the Swedish Institute via the Visby short-term research stay program and Ukrainian government via the International internship program.

Author information

Authors and Affiliations

  1. Analytical Chemistry Department, Oles Honchar Dnipropetrovsk National University, av.Gagarina72, 49050, Dnipropetrovsk, Ukraine

    O. Gurtova & F. Chmilenko

  2. Pure and Applied Biochemistry, Chemical Center, Lund University, Box 124, 221 00, Lund, Sweden

    L. Ye

Authors
  1. O. Gurtova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Chmilenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. Gurtova.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gurtova, O., Ye, L. & Chmilenko, F. Potentiometric propranolol-selective sensor based on molecularly imprinted polymer. Anal Bioanal Chem 405, 287–295 (2013). https://doi.org/10.1007/s00216-012-6493-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-012-6493-6

Keywords

Search

Navigation