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Microbial interactions in Staphylococcus epidermidis biofilms

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Abstract

Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. The formation of adherent, multilayered bacterial biofilms is the most important factor in the pathogenesis of these infections, which regularly fail to respond to appropriate antimicrobial therapy. Progress in elucidating the factors functional in elaboration of S. epidermidis biofilms and the regulation of their expression with a special emphasis on the role of quorum sensing are reviewed. Significant progress has been made in recent years, which provides the rationale for developing better preventive, therapeutic and diagnostic measures.

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Acknowledgement

We would like to thank the AO Research Institute, Davos, Switzerland, for use of their SEM.

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Authors and Affiliations

  1. Medical Microbiology and Infectious Diseases, The School of Medicine, Swansea University, Grove Building, Singleton Park, Swansea, SA2 8PP, UK

    Dietrich Mack, Angharad P. Davies & Llinos G. Harris

  2. Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Zentrum für Klinische Pathologie, Universitäts-Klinikum Hamburg-Eppendorf, 20246, Hamburg, Germany

    Holger Rohde

  3. Bioscientia, Institut für Medizinische Diagnostik, Regionallabor Moers, Zum Schürmannsgraben 30, 47441, Moers, Germany

    Matthias A. Horstkotte

  4. Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck, 23538, Lübeck, Germany

    Johannes K.-M. Knobloch

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  1. Dietrich Mack
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Mack, D., Davies, A.P., Harris, L.G. et al. Microbial interactions in Staphylococcus epidermidis biofilms. Anal Bioanal Chem 387, 399–408 (2007). https://doi.org/10.1007/s00216-006-0745-2

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