Skip to main content
SpringerLink
Log in

LC/MS determination of bisphenol A in river water using a surface-modified molecularly-imprinted polymer as an on-line pretreatment device

  • Original Paper
  • Published:
Analytical and Bioanalytical Chemistry Aims and scope Submit manuscript

Abstract

A new analytical method for the determination of bisphenol A (BPA) by LC/MS was developed and applied to environmental water samples. Quantitative MS detection of BPA was carried out in the negative mode. In order to preconcentrate the target compound yet prevent serious contamination of the water samples from the experimental environment, we employed column switching HPLC coupled with a pretreatment column of surface-modified molecularly-imprinted polymers. The recovery of BPA from a spiked environmental water sample was 102% and the repeatability of actual determinations of water samples containing 20 ng/L of BPA was 5.4% RSD. By modifying the surfaces of the molecularly-imprinted polymer particles packed in the pretreatment column, interference from the water samples was effectively removed, resulting in a significant increase in sensitivity and more reliable results. This method was successfully applied to the trace determination of BPA in environmental water samples using LC/MS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Vom Saal FS, Cooke PS, Buchanan DL, Paianza P, Thayer KA, Nagel SC, Parmigiani S, Welshons WV (1998) Toxicol Ind Health 14:239

    Google Scholar 

  2. Fisher JS, Turner KJ, Brown D, Sharpe RM (1999) Environ Health Perspect 107:397

    Google Scholar 

  3. Steinmetz R, Mitchner NA, Grant A, Allen DL, Bigsby RM, Ben-Jonathan N (1997) Endocrinology 138:1780

    Google Scholar 

  4. Sajiki J, Takahashi K, Yonekubo J (1999) J Chromatogr B 736:255

    Google Scholar 

  5. Sajiki J (2001) J Chromatogr B 775:9

    Google Scholar 

  6. Wercinski SAS (1999) Solid phase microextraction: a practical guide. Marcel Dekker, New York

    Google Scholar 

  7. Thurman EM, Mills MS (1998) Solid-phase extraction. Wiley, New York

    Google Scholar 

  8. Bartsch RA, Maeda M (1998) Molecular and ionic recognition with imprinted polymers. American Chemical Society, Washington DC

    Google Scholar 

  9. Sellergren B (2001) Molecularly imprinted polymers. Elsevier, Amsterdam

    Google Scholar 

  10. Kubo T, Hosoya K, Watabe Y, Ikegami T, Tanaka N, Sano T, Kaya K (2003) J Chromatogr A 1:987–389

    Google Scholar 

  11. Haginaka J, Sanbe H (2000) Anal Chem 72:5206

    Google Scholar 

  12. Jodlbauer J, Lindner W, Maier NM (2000) J Chromatogr A 945:45

    Google Scholar 

  13. Matsuki J, Fujiwara K, Takeuchi T (2000) Anal Chem 72:1810

    Google Scholar 

  14. Quaglia M, Hall AJ, Chenon K, Lorenzi ED, Sellergren B (2001) J Am Chem Soc 123:2146

    Google Scholar 

  15. Watabe Y, Hosoya K, Tanaka N, Kubo T, Kondo T, Morota M (2004) Chem Lett 33: 806

    Google Scholar 

  16. Watabe Y, Kondo T, Imai H, Morita M, Tanaka N, Haginaka J, Hosoya KJ (2004) J Chromatogr A 1032:45

    Article  CAS  PubMed  Google Scholar 

  17. Watabe Y, Hosoya K, Tanaka N, Kubo T, Kondo T, Morota M (2004) J Chromatogr A (in press)

  18. Perrin DD, Armarego WLF, Perrin DR (1980) Purification of laboratory chemicals. Pergamon, Oxford

    Google Scholar 

  19. Smigol V, Svec F, Hosoya K, Wang Q, Frechet JMJ (1992) Angew Macromol Chem 195:151

    Google Scholar 

  20. Hosoya K, Frechet JMJ (1993) J Polym Sci Part A 31:2129

    Google Scholar 

Download references

Acknowledgements

This research was partly supported by the Nanotechnology Project of the Ministry of Environment and a Grant-in-Aid for Basic Scientific Research (No. 14042232 & 16350082) from the Ministry of Education, Science, Sport, and Culture of Japan.

Author information

Authors and Affiliations

  1. Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, 606-8585, Japan

    Yoshiyuki Watabe, Ken Hosoya & Nobuo Tanaka

  2. Endocrine Disrupters Research Laboratory, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan

    Takuya Kondo & Masatoshi Morita

  3. Graduate School of Environmental Studies, Tohoku University, Aoba 20, Aramaki, Aoba-ku, Sendai, 980-8579, Japan

    Takuya Kubo

Authors
  1. Yoshiyuki Watabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ken Hosoya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nobuo Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takuya Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masatoshi Morita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takuya Kubo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ken Hosoya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Watabe, Y., Hosoya, K., Tanaka, N. et al. LC/MS determination of bisphenol A in river water using a surface-modified molecularly-imprinted polymer as an on-line pretreatment device. Anal Bioanal Chem 381, 1193–1198 (2005). https://doi.org/10.1007/s00216-004-3031-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00216-004-3031-1

Keywords

Search

Navigation