Abstract.
The principles of diffraction are utilized to enable the simultaneous detection of multiple analytes in solution, forming the basis of a multi-analyte sensor. Probe molecules are immobilized on a substrate such that each type of molecule defines a specific pattern within the same region of substrate. The binding of a target molecule to its complementary probe is heralded by a characteristic diffraction image. This principle is demonstrated using antibody conjugates.
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Goh, J., Loo, R.W., McAloney, R.A. et al. Diffraction-based assay for detecting multiple analytes. Anal Bioanal Chem 374, 54–56 (2002). https://doi.org/10.1007/s00216-002-1478-5
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DOI: https://doi.org/10.1007/s00216-002-1478-5