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Preparation of refractive index matching polymer film alternative to oil for use in a portable surface-plasmon resonance phenomenon-based chemical sensor method

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Abstract

In order to simplify the procedure for assembling a surface-plasmon resonance (SPR) sensor, a refractive index matching polymer film was prepared as an alternative to the conventionally used matching oil. The refractive index matching polymer film, the refractive index of which was nearly equal to the prism and sensor chip material (a cover glass) of the SPR sensor, was prepared by casting a tetrahydrofuran solution of poly (vinyl chloride) (PVC) containing equal weights of dioctyl phthalate and tricresyl phosphate. The refractive index matching polymer film was found to have a refractive index of 1.516, which is identical to that of the prism and the cover glass used for the present SPR sensor. The utility of the matching polymer film for the SPR sensor was confirmed by the detection of anti-human albumin, based on an antigen-antibody reaction.

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Authors and Affiliations

  1. Department of Chemical Science and Engineering, Ariake National College of Technology, Omuta, Fukuoka 836–8585, Japan, Japan

    Takashi Masadome

  2. Department of Chemical and Biological Engineering, Hachinohe National College of Technology, Hachinohe, Aomori 039–1192, Japan, Japan

    Yasukazu Asano & Satoshi Ohkubo

  3. Department of Chemical Systems and Engineering, Graduate School of Engineering, Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812–8581, Japan, Japan

    Toshihiko Imato

  4. NTT Advanced Technology Corporation, Tokai-mura, Naka-gun, Ibaraki, 319–1193, Japan, Japan

    Tatsuya Tobita & Hisao Tabei

  5. NTT Lifestyle and Environmental Technology Laboratories, NTT Corporation, Atsugi, Kanagawa 243–0198, Japan, Japan

    Yuzuru Iwasaki & Osamu Niwa

  6. Scientific Investigation Research Laboratory, Kagoshima Prefecture Police H.Q., Kamoike-shinmachi, Kagoshima, 890–8566, Japan, Japan

    Yoshito Fushinuki

Authors
  1. Takashi Masadome
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  2. Yasukazu Asano
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  3. Toshihiko Imato
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  4. Satoshi Ohkubo
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  5. Tatsuya Tobita
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  6. Hisao Tabei
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  7. Yuzuru Iwasaki
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  8. Osamu Niwa
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  9. Yoshito Fushinuki
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Masadome, T., Asano, Y., Imato, T. et al. Preparation of refractive index matching polymer film alternative to oil for use in a portable surface-plasmon resonance phenomenon-based chemical sensor method. Anal Bioanal Chem 373, 222–226 (2002). https://doi.org/10.1007/s00216-002-1329-4

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  • DOI: https://doi.org/10.1007/s00216-002-1329-4

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