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Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking

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Abstract

Rationale

The attraction to alcohol can be greatly increased when it is consumed in a social context. While pro-social interactions can potentiate voluntary alcohol drinking under some conditions, aversive social experience (i.e., social stress) can similarly intensify alcohol consumption.

Objective

We sought to determine how exposure to different types of chronic social stress (i.e., intermittent episodes of social defeat or continuous social stress) influences alcohol consumption and the reinforcing effects of alcohol in mice with a history of drinking.

Methods

Separate cohorts of male C57BL/6J mice were exposed to either 10 days of continuous or intermittent social defeat stress. In experiment 1, mice were assigned to 20% w/v alcohol consumption in a two-bottle choice protocol both prior to and after exposure to social defeat stress. In a second experiment, mice engaged in an operant response sequence to gain access to alcohol wherein completion of a fixed interval (FI; 5 min) schedule was reinforced with continuous access to alcohol (fixed ratio; FR1) for up to 1.8 g/kg. Alcohol-reinforced responding and subsequent alcohol consumption were assessed daily for 4 weeks prior to the 10-day social stress exposure and for 6-week post-stress. Machine learning was implemented to standardize the analysis of defeat behaviors exhibited by the intruder mouse during confrontation with an attacking resident.

Results

In mice with a prior history of alcohol drinking, intermittent episodes of social defeat stress produced a significant increase in 20% EtOH consumption in preference over concurrently available water. This increased intake persisted for at least 6 weeks after the final social stress experience. Intermittently stressed mice also accelerated their anticipatory responding during the fixed interval component of the operant response chain that was reinforced by alcohol. Neither unstressed controls nor mice exposed to continuous social stress exhibited significant increases in alcohol consumption and alcohol reinforcement.

Discussion

Episodic social defeat stress promotes the seeking and consumption of alcohol, extending earlier work to alcohol-experienced mice. We hypothesize that intermittent access to alcohol and intermittent episodes of social stress are additive and share common sensitizing neural mechanisms that engender excessive alcohol consumption.

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Acknowledgements

The authors would like to thank J. Thomas Sopko, Rebecca Atherton, Kathryn Hazzard, William Hsu, Samar Shaqour, and Annika Witt for their assistance.

Funding

This work was supported by NIH grants AA013983 and DA031734 (KAM).

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Authors and Affiliations

  1. Department of Psychology, Tufts University, Medford, MB, 02155, USA

    Klaus A. Miczek, Naz Akdilek, Vania M. M. Ferreira, Elizabeth Kenneally, Michael Z. Leonard & Herbert E. Covington III

  2. Department of Neuroscience, Tufts University, Boston, MA, 02111, USA

    Klaus A. Miczek

  3. Universidade de Brasilia, Brasilia, DF, Brazil

    Vania M. M. Ferreira

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  1. Klaus A. Miczek
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Miczek, K.A., Akdilek, N., Ferreira, V.M.M. et al. Excessive alcohol consumption after exposure to two types of chronic social stress: intermittent episodes vs. continuous exposure in C57BL/6J mice with a history of drinking. Psychopharmacology 239, 3287–3296 (2022). https://doi.org/10.1007/s00213-022-06211-8

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