Abstract
Rationale
Although studies suggest that stress is an important reason for relapse in alcoholics, few controlled studies have been conducted to examine this assumption. Evidence of stress-potentiated drinking would substantiate this clinical observation and would contribute to the development of a model that would be valuable to alcohol treatment research.
Objectives
The hypothesis was tested that an acute psychosocial stressor, the Trier Social Stress Test (TSST), increases alcohol consumption in non-treatment-seeking alcoholics.
Methods
Seventy-nine alcohol-dependent participants (40 women) were randomly assigned to receive the TSST or a no-stress condition. Immediately afterward, all participants received an initial dose of their preferred alcoholic beverage to achieve a target blood alcohol concentration of 0.03 g/dl (to prime subsequent drinking in the laboratory). Participants then participated in a mock taste test of two glasses of beer. Primary dependent measures were whether s/he drank all of the beer available (yes/no) and total amount of beer consumed (milliliters).
Results
Stressed participants were twice as likely as non-stressed participants to drink all of the beer available, a significant effect. Although the stressed group drank more milliliters than the non-stressed group, this effect failed to reach significance, likely due to ceiling effects. There were no significant stress group × gender effects on either outcome.
Conclusions
This study supports that stress-potentiated drinking is valid and can be modeled in a clinical laboratory setting.
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Acknowledgments
This research was supported by a grant from NIAAA to the Charleston Alcohol Research Center (P50 AA010761) and by support from the National Center for Research Resources (M01 RR01070).
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The authors declare no conflicts of interest.
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Thomas, S.E., Bacon, A.K., Randall, P.K. et al. An acute psychosocial stressor increases drinking in non-treatment-seeking alcoholics. Psychopharmacology 218, 19–28 (2011). https://doi.org/10.1007/s00213-010-2163-6
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DOI: https://doi.org/10.1007/s00213-010-2163-6