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Polygonum ciliinerve (Nakai) Ohwi: a review of its botany, traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology

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Abstract

Polygonum ciliinerve (Nakai) Ohwi is a perennial twining vine plant from the Polygonaceae family, which is a Chinese herbal medicine with great value for development and utilization. The purpose of this paper is to provide a systematic review of the botany, traditional uses, phytochemistry, pharmacology, pharmacokinetics, and toxicology of Polygonum ciliinerve (Nakai) Ohwi, as well as an outlook on the future research directions and development prospects of the plant. Data on Polygonum ciliinerve (Nakai) Ohwi were obtained from different databases, including China National Knowledge Infrastructure, Baidu Academic, Wanfang Database, Google Academic, PubMed, Web of Science, SpringerLink, Wiley; books; standards; and Ph.D. and MSc theses. So far, 86 compounds have been identified from Polygonum ciliinerve (Nakai) Ohwi, including anthraquinones, stilbenes, flavonoids, tannins, chromogenic ketones, organic acids and esters, lignans, isobenzofurans, alkaloids, naphthols, and others. Studies have found that Polygonum ciliinerve (Nakai) Ohwi has a wide range of pharmacological effects, including antiviral, antibacterial, anti-inflammatory and analgesic, antitumor, immunomodulatory, hypoglycemic, and antioxidant effects. Clinically, Polygonum ciliinerve (Nakai) Ohwi is very effective in the treatment of gastritis and chronic gastritis. Based on its traditional use, chemical composition, and pharmacological activity, Polygonum ciliinerve (Nakai) Ohwi is a promising source of natural medicine in drug development.

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Data availability

No datasets were generated or analysed during the current study.

Abbreviations

PCO:

Polygonum ciliinerve (Nakai) Ohwi

NMPN:

National Medicine Permission Number

HSV – I:

Herpes simplex virus—I

HSV – II:

Herpes simplex virus—II

CCK-8:

Cell counting kit-8

EV-A71:

Enterovirus type A71

ZIKV:

Zika virus

IL-2:

Interleukin-2

TNF-α:

Tumor necrosis factor-α

TGEV:

Swinetransmissible gastroenteritis virus

ST:

Swine testis

NDV:

Newcastle disease virus

MDCK:

Madin-darby canine kidney

MBC:

Minimum bactericidal concentration

TLRs/NODs:

Toll-like receptors/ Nod-like receptors

TNF-α:

Tumor necrosis factor-α

IL-6:

Interleukin-6

EGFR:

Epidermal growth factor receptor

MAPK:

Mitogen-activated protein kinase

NF-κB:

Nuclear factor kappa-B

GES-1:

Gastric mucosa epithelial cells-1

IgG:

Immunoglobulin G

IC50 :

Half maximal inhibitory concentration

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Acknowledgements

We would like to thank every author who so kindly provided extra information and comprehensive data from their research for this systematic review. This work was supported by the Project of Education Department of Shaanxi Provincial government [grant number 21JC011], the Project of Shaanxi Administration of Traditional Chinese Medicine [grant number 2021-04-ZZ-0072021‐04‐ZZ‐007].

Funding

This work was supported by the Project of Education Department of Shaanxi Provincial government [grant number 21JC011], the Project of Shaanxi Administration of Traditional Chinese Medicine [grant number 2021-04-ZZ-0072021‐04‐ZZ‐007].

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Authors and Affiliations

  1. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China

    Qiong Qu, Ying Zhang, Xiaomei Zhao, Xinbo Zhang, Xuan Wei, Yingying Tang, Xuan Lei & Xiao Song

  2. Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing, 100029, China

    Xiao Song

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Contributions

QQ: project administration, methodology, formal analysis, results interpretation, writing review, and editing. ZZ: completed Figs. 1 and 2. ZXM: completed Figs. 3 and 4. ZXB: completed Figs. 5 and 6. WX: literature search, study screening. TYY: completed Tables 1, 2, and 3. LX: systemically revised the manuscript for important content. SX: proposed the conception and designed the structure of the manuscript. All authors reviewed and approved the manuscript for submission. The authors confirm that no paper mill and artificial intelligence was used.

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Correspondence to Xiao Song.

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Qu, Q., Zhang, Y., Zhao, X. et al. Polygonum ciliinerve (Nakai) Ohwi: a review of its botany, traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-024-03015-9

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