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Effects of the suppression of 5-HT1A receptors in the left, right, or bilateral basolateral amygdala on memory consolidation in chronic stress in male rats

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Abstract

The serotonin-1A receptors (5-HT1A) in the two cerebral hemispheres are differentially involved in memory. The distribution of 5-HT1A receptors in the left and right amygdala is different. Furthermore, evidence shows that the 5-HT1A receptors in the left and right amygdala work differently in memory function. The basolateral amygdala (BLA) also regulates hippocampal long-term potentiation (LTP) during stress. However, which BLA structure in each hemisphere underlies such lateralized function is unclear. The present research investigated the possible involvement of 5-HT1A lateralization in the BLA on stress-induced memory impairment. 5-HT1A receptor antagonist (Way-100-635) was injected into the left, right, or bilateral BLA twenty minutes before chronic restraint stress (CRS) for 14 consecutive days. Results indicated that suppression of 5HT1A-receptors in the BLA plays an essential role in reducing the acquisition of passive avoidance in the shuttle box test and spatial memory in the Barnes maze test in the stress animals. This decrease was significant in the CRS animals with left and bilateral suppressed 5HT1A-receptors in the BLA. Field potential recording results showed that the left, right, and bilateral injection of Way-100-635 into the BLA significantly reduced the slope and amplitude of fEPSP in the CA1 area of the hippocampus in stressed rats. No significant difference was observed in neuronal arborization in the CA1 area of the hippocampus. In conclusion, the 5-HT1A receptor in the left and right sides of BLA nuclei play a different role in memory consolidation in the hippocampus under stress.

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Acknowledgements

This study was supported by Neuroscience Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

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Authors and Affiliations

  1. Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Habib Valipour, Gila Pirzad Jahromi, Alireza Mohammadi & Gholam Hossein Meftahi

  2. Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Habib Valipour

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  1. Habib Valipour
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HV collected data and wrote the manuscript under the supervision of GHM. GPJ and AM Methodology. GHM designed the experiment, collected data, analyzed data, and wrote the manuscript. All authors read and approved the final manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

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Correspondence to Gholam Hossein Meftahi.

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Valipour, H., Jahromi, G.P., Mohammadi, A. et al. Effects of the suppression of 5-HT1A receptors in the left, right, or bilateral basolateral amygdala on memory consolidation in chronic stress in male rats. Naunyn-Schmiedeberg's Arch Pharmacol 397, 3049–3064 (2024). https://doi.org/10.1007/s00210-023-02790-1

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