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Phytochemistry and biological activity of Erigeron annuus (L.) Pers

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Abstract

Erigeron annuus L. is a flowering herb of North America, Europe, Asia and Russia. This plant is used as folk medicine in China for the cure of indigestion, enteritis, epidemic hepatitis, haematuria and diabetes. Phytochemical studies showed the presence of 170 bioactive compounds like coumarins, flavonoids, terpenoids, polyacetylenic compounds; γ-pyrone derivatives, sterols and various caffeoylquinic acids derived from the essential oil and organic extracts from its various parts such as aerial parts, roots, leaves, stems and flowers. The pharmacological studies demonstrated various extracts and the compounds of E. annuus to exhibit anti-fungal, anti-atherosclerosis, anti-inflammatory, antidiabetic, phytotoxic, cytoprotective, antiobesity and antioxidant activities. This article covers a critical compendious on geographical distribution, botanical description, phytochemistry, ethnomedicinal uses and pharmacological activities of E. annuus. However, further in-depth studies are needed to determine the medical uses of E. annuus and its chemical constituents, pharmacological activities and clinical applications.

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Abbreviations

E. annuus :

Erigeron annuus

GC/MS:

Gas chromatography/mass spectrometry

RI:

Retention index

1H NMR:

Hydrogen nuclear magnetic resonance

ACAT, acyl-CoA:

Cholesterol acyltransferase

HaCaT:

Human epidermal keratinocyte cell line

Lp-PLA2:

Lipoprotein-associated phospholipase A2 enzyme

LDL:

Low density lipoprotein

NO:

Nitric oxide

PGE 2 :

Prostaglandin E2

TNF-α:

Tumour necrosis factor

IL-1β :

Interleukin-1

iNOS:

Nitric oxide synthases

COX-2:

Cyclooxygenase-2

LPS:

Lipopolysaccharides

NF-Κb:

Nuclear factor kappa light chain enhancer of activated B cells

ppm:

Parts per million

IC:

Inhibitory concentration

AGES:

Advanced glycation end products

RLAR:

Rat lens aldose reductase

BEL7402:

Human liver carcinoma cell

SRB:

Sulphorhodamine

DMSO:

Dimethylsulfoxide

MTCC:

Microbial type culture collection

EO:

Essential oil

ABTS:

2,2′-Azinobis-(3-ethylenebenzothiazoline)-6-sulfonic acid

EC:

Effective concentration

PC:

Pheochromocytoma

DCFH-DA:

2’,7’-Dichlorofluorescein diacetate

LDH:

Lactate dehydrogenase

AD:

Alzheimer’s disease

MFC:

For minimal fungicidal concentrations

MIC:

Minimum inhibitory concentration

EC :

Escherichia coli

PA:

Pseudomonas aeruginosa

AH:

Aeromonas hydrophila

KP:

Klebsiella pneumoniae

BS:

Bacillus subtilis

SC:

Steptomyces candidus

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Author notes

  1. Rupali Rana and Swati Pundir contributed equally on this paper.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India

    Rupali Rana

  2. School of Pharmaceutical Sciences, Shoolini University, Himachal Pradesh, Solan, 173229, India

    Swati Pundir, Uma Ranjan Lal & Raveen Chauhan

  3. Department of Natural Products, National Institute of Pharmaceutical Education and Research, Punjab, 160062, Mohali, India

    Uma Ranjan Lal

  4. Department of Botany, Panjab University, Chandigarh, Punjab, India

    Santosh Kumar Upadhyay

  5. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Himachal Pradesh, Solan, 173229, India

    Deepak Kumar

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  1. Rupali Rana
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Contributions

R.R: Collection of the information, drafting of the manuscript; U.R.L., R.C.: Data curation; SP, S.K.U and DK: Analysis, review and editing. All authors approved the final submitted version of the manuscript. The authors confirm that no paper mill and artificial intelligence was used.

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Rana, R., Pundir, S., Lal, U.R. et al. Phytochemistry and biological activity of Erigeron annuus (L.) Pers. Naunyn-Schmiedeberg's Arch Pharmacol 396, 2331–2346 (2023). https://doi.org/10.1007/s00210-023-02518-1

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