Abstract
Male Wistar rats were given ethanediol (9.4 g/l), 2-ethoxyethylacetate (5.4 g/l), 2-butoxyethylacetate (2.9 g/l) and 1,2-propanediol (40 g/l) respectively in their drinking water for 2 weeks. Urine was collected during the last 24 h of the exposure. There was a marked increase in the oxalic acid excretion by the rats given ethanediol while rats given the alkoxyacetates excreted large amounts of ethoxyacetic and butoxyacetic acid, respectively. While not increased compared with controls, the excretion of oxalic acid by the latter group of rats was correlated to the excretion of the respective alkoxyacetic acids. The ammonia and glycosaminoglycan excretion was also smaller than that of controls. The urinary activity of succinate dehydrogenase was decreased in rats given the alkoxyacetates but not in animals exposed to ethanediol or propanediol. The data show that oxalic acid is actually a minor metabolite of the alkoxyacetates while the biochemical effects in kidney are associated more with the alkoxyacetic acid load. Alkoxyacetic acids seem to be inhibitors of renal succinate dehydrogenase, which may account for the decreased ammonia and glycosaminoglycan excretion.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 19 April 1999 / Accepted: 21 April 1999
Rights and permissions
About this article
Cite this article
Liesivuori, J., Laitinen, J. & Savolainen, H. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Arch Toxicol 73, 229–232 (1999). https://doi.org/10.1007/s002040050611
Issue Date:
DOI: https://doi.org/10.1007/s002040050611