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Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite

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Abstract

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1 ξ 10−5 M DTMA.

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Authors and Affiliations

  1. Institute for Biomedical Research Teijin Ltd, 4-3-2 Asahigaoka, 191, Hino, Japan

    Yoshihiro Yamanaka, Emiko Sakamoto, Yasuji Sakuma, Hiroshi Uno, Tamotsu Koyama & Yoshihiro Izawa

  2. Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, 252, Fujisawa, Japan

    Yoshihiro Yamanaka & Kosaku Fujiwara

Authors
  1. Yoshihiro Yamanaka
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  2. Emiko Sakamoto
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  3. Yasuji Sakuma
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  4. Hiroshi Uno
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  5. Tamotsu Koyama
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  6. Yoshihiro Izawa
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  7. Kosaku Fujiwara
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Yamanaka, Y., Sakamoto, E., Sakuma, Y. et al. Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite. Arch Toxicol 69, 391–396 (1995). https://doi.org/10.1007/s002040050189

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  • DOI: https://doi.org/10.1007/s002040050189

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