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The relationship between autophagy and respiratory viruses

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Abstract

Respiratory viruses have caused severe global health problems and posed essential challenges to the medical community. In recent years, the role of autophagy as a critical process in cells in viral respiratory diseases has been noticed. One of the vital catabolic biological processes in the body is autophagy. Autophagy contributes to energy recovery by targeting and selectively directing foreign microorganisms, organelles, and senescent intracellular proteins to the lysosome for degradation and phagocytosis. Activation or suppression of autophagy is often initiated when foreign pathogenic organisms such as viruses infect cells. Because of its antiviral properties, several viruses may escape or resist this process by encoding viral proteins. Viruses can also use autophagy to enhance their replication or prolong the persistence of latent infections. Here, we provide an overview of autophagy and respiratory viruses such as coronavirus, rhinovirus, parainfluenza, influenza, adenovirus, and respiratory syncytial virus, and examine the interactions between them and the role of autophagy in the virus–host interaction process and the resulting virus replication strategy.

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Authors and Affiliations

  1. Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Hamidreza Gheitasi, Mohammad Sabbaghian, Nader Mohammadzadeh & Vahdat Poortahmasebi

  2. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Manouchehr Fadaee

  3. Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Ali Akbar Shekarchi

  4. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran

    Vahdat Poortahmasebi

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Contributions

HG, MS: Writing—review and editing, writing—original draft. MF: prepared figures 1-2. NM, AAS: Writing and editing. VP: Writing—review and editing, project administration, investigation, conceptualization.

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Gheitasi, H., Sabbaghian, M., Fadaee, M. et al. The relationship between autophagy and respiratory viruses. Arch Microbiol 206, 136 (2024). https://doi.org/10.1007/s00203-024-03838-3

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