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Microbial biofilm ecology, in silico study of quorum sensing receptor-ligand interactions and biofilm mediated bioremediation

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Abstract

Biofilms are structured microbial communities of single or multiple populations in which microbial cells adhere to a surface and get embedded in extracellular polymeric substances (EPS). This review attempts to explain biofilm architecture, development phases, and forces that drive bacteria to promote biofilm mode of growth. Bacterial chemical communication, also known as Quorum sensing (QS), which involves the production, detection, and response to small molecules called autoinducers, is highlighted. The review also provides a brief outline of interspecies and intraspecies cell–cell communication. Additionally, we have performed docking studies using Discovery Studio 4.0, which has enabled our understanding of the prominent interactions between autoinducers and their receptors in different bacterial species while also scoring their interaction energies. Receptors, such as LuxN (Phosphoreceiver domain and RecA domain), LuxP, and LuxR, interacted with their ligands (AI-1, AI-2, and AHL) with a CDocker interaction energy of − 31.6083 kcal/mole; − 34.5821 kcal/mole, − 48.2226 kcal/mole and − 41.5885 kcal/mole, respectively. Since biofilms are ideal for the remediation of contaminants due to their high microbial biomass and their potential to immobilize pollutants, this article also provides an overview of biofilm-mediated bioremediation.

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Acknowledgements

Financial assistance provided by NASF research grant (Project entitled “Bioremediation of chemical contaminants and their complexes present in drainage water with high dynamic flux used for irrigation in urban and periurban agriculture”), sanction no. NASF/CA-6030/2017-2018 is highly acknowledged.

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Authors and Affiliations

  1. Soil Microbial Ecology and Environment Toxicology Laboratory, Department of Zoology, University of Delhi, Delhi, 110007, India

    Biji Balan, Amit S. Dhaulaniya, Kushneet K. Sodhi, Mohit Kumar & Dileep Kumar Singh

  2. Bio-Organic Chemistry Laboratory, Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi, 110007, India

    Diksha A. Varma & Manisha Tiwari

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  1. Biji Balan
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  2. Amit S. Dhaulaniya
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Correspondence to Dileep Kumar Singh.

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Balan, B., Dhaulaniya, A.S., Varma, D.A. et al. Microbial biofilm ecology, in silico study of quorum sensing receptor-ligand interactions and biofilm mediated bioremediation. Arch Microbiol 203, 13–30 (2021). https://doi.org/10.1007/s00203-020-02012-9

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