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Uncertain Future of Trials in Osteoporosis

  • Review Article
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Osteoporosis International Aims and scope Submit manuscript

Abstract:

The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.

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Authors and Affiliations

  1. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK, UK

    J. A. Kanis

  2. Solberg, Romelanda, Sweden, Sweden

    A. Oden

  3. Department of Orthopaedics, Malmo¨ General Hospital, Sweden, Sweden

    O. Johnell

  4. FC Consulting SA, Paris, France, France

    F. Caulin

  5. Michigan Bone & Mineral Clinic, Detroit, Michigan, USA, USA

    H. Bone

  6. Ho^pital Europe´en George Pompidou, Paris, France, France

    J.-M. Alexandre

  7. AFFSAPS, 143 bd Anatole France, St Denis, France;, France

    E. Abadie

  8. Medicines Evaluation Board, The Netherlands, The Netherlands

    F. Lekkerkerker

Authors
  1. J. A. Kanis
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  2. A. Oden
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  3. O. Johnell
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  4. F. Caulin
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  5. H. Bone
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  6. J.-M. Alexandre
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  7. E. Abadie
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  8. F. Lekkerkerker
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Additional information

Received: 19 December 2001 / Accepted: 11 March 2002

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Kanis, J., Oden, A., Johnell, O. et al. Uncertain Future of Trials in Osteoporosis. Osteoporos Int 13, 443–449 (2002). https://doi.org/10.1007/s001980200052

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  • DOI: https://doi.org/10.1007/s001980200052

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