Skip to main content

Advertisement

SpringerLink
Log in

Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study

  • Short Scientific Communication
  • Published:
Osteoporosis International Aims and scope Submit manuscript

Abstract

Purpose

T50 is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T50 indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T50 nor the relationships of T50 with bone mineral density (BMD) are known.

Methods

We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T50 and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T50 and hip and spine BMD in multivariable models.

Results

Older age was associated with shorter T50. Kidney function tended to be lower in those with shorter T50 and the prevalence of CVD and peripheral arterial disease in those with shorter T50, albeit these findings did not achieve statistical significance. We found no statistically significant associations between T50 and total hip or total spine BMD in either unadjusted or multivariable adjusted models.

Conclusions

T50, a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T50 may give insights to CVD in the general population above and beyond traditional risk factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726–1733

    Article  CAS  PubMed  Google Scholar 

  2. Cauley JA, Fullman RL, Stone KL, Zmuda JM, Bauer DC, Barrett-Connor E, Ensrud K, Lau EMC, Orwoll ES, For the Mr. OS Research Group (2005) Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int 16(12):1525–1537

    Article  PubMed  Google Scholar 

  3. Pasch A, Farese S, Graber S, Wald J, Richtering W, Floege J, Jahnen-Dechent W (2012) Nanoparticle-based test measures overall propensity for calcification in serum. J Am Soc Nephrol 23(10):1744–1752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Dahle DO, Asberg A, Hartmann A et al (2016) Serum calcification propensity is a strong and independent determinant of cardiac and all-cause mortality in kidney transplant recipients. Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg 16(1):204–212

    Article  CAS  Google Scholar 

  5. Smith ER, Ford ML, Tomlinson LA, Bodenham E, McMahon LP, Farese S, Rajkumar C, Holt SG, Pasch A (2014) Serum calcification propensity predicts all-cause mortality in predialysis CKD. J Am Soc Nephrol 25(2):339–348

    Article  CAS  PubMed  Google Scholar 

  6. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26(5):569–585

    Article  PubMed  Google Scholar 

  7. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR (2005) Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 26(5):557–568

    Article  PubMed  Google Scholar 

Download references

Funding

Dr. Alexander L. Bullen was supported by a Ruth L. Kirschstein training grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK; T32DK104717). Dr. Joachim H. Ix was supported by a midcareer mentoring award from the NIDDK (K24DK110427). Measurements were supported from an award from the American Heart Association to Dr. Joachim H. Ix (14EIA18560026).

The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.

Author information

Authors and Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA

    A. L. Bullen, C. A. M. Anderson & J. H. Ix

  2. Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA

    C. A. M. Anderson & D. M. Kado

  3. Center to Improve Veteran Involvement in Care (CIVIC), VA Portland Health Care System, Portland, OR, USA

    E. R. Hooker

  4. Oregon Health & Science University School of Medicine, Portland, OR, USA

    E. Orwoll

  5. Calciscon, Nidau, Biel, Switzerland

    A. Pasch

  6. Nephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA

    J. H. Ix

Authors
  1. A. L. Bullen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. M. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. R. Hooker
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. M. Kado
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Orwoll
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Pasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. J. H. Ix
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. H. Ix.

Ethics declarations

Conflicts of interest

Andreas Pasch is an inventor of the T50-Test and co-founder, stock-holder, and employee of Calciscon Ltd., Nidau, Switzerland, which commercializes the T50-Test. Dr. Orwoll has received research support from Lilly and Mereo Biopharma and has provided consulting for Bayer. Alexander L Bullen, Cheryl A.M Anderson, Elizabeth R. Hooker, Deborah M. Kado, and Joachim H. Ix declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bullen, A.L., Anderson, C.A.M., Hooker, E.R. et al. Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study. Osteoporos Int 30, 1529–1531 (2019). https://doi.org/10.1007/s00198-019-04925-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00198-019-04925-8

Keywords

Search

Navigation