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Individual site-specific bone mineral density gain in normocalcemic primary hyperparathyroidism

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Abstract

Summary

In this study, we show that successful parathyroidectomy is followed at 1 year by a significant individual bone mineral density (BMD) gain in nearly half of normocalcemic PHPT patients with reduced bone mass. Alkaline phosphatase levels above median were identified as an independent predictor of individual BMD gain in normocalcemic PHPT patients.

Introduction

The aims of this study were to assess bone mineral density (BMD) gains after parathyroidectomy (PTX) in normocalcemic primary hyperparathyroidism (PHPT) at the individual level and to identify predictors of BMD gain after PTX in this context.

Methods

Longitudinal cohort study of 55 PHPT patients referred for low bone mass and mild abnormalities of calcium/phosphorus metabolism, and successfully treated by PTX. BMD gain at 1 year was considered significant if ≥0.030 g/cm2 at one site or more, without any equivalent BMD loss at another site. A logistic regression analysis was performed to identify predictive factors of individual BMD gain.

Results

Among the 55 PHPT patients included, 29 patients with hypercalcemia, 36 patients with normocalcemic PHPT, defined by normal pre-PTX serum total (albumin-corrected) calcium (tCa), including 15 patients with normal ionized calcium (iCa), were identified. At 1 year of PTX, an individual BMD gain was observed in 73.7 % of hypercalcemic, 44.4 % of normocalcemic, and 46 % of PHPT patients with both normal tCa and iCa. Site-specific BMD gains were most important at the spine and hip in all subgroups including patients with normal iCa. Alkaline phosphatase activity above median, which reflects high bone turnover, was predictive of individual BMD gain, both in the overall cohort (OR = 4.9, 95 % CI 1.3–18.9), and in the normocalcemic group: OR = 8.4, 95 % CI 1.4–56.6.

Conclusions

Successful PTX is followed at 1 year by a significant individual BMD gain in nearly half of normocalcemic PHPT patients with osteoporosis. ALP levels above median could contribute to the therapeutic decision in this context.

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Authors and Affiliations

  1. Department of Rheumatology A, Cochin Hospital, APHP, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France

    E. Koumakis, J. Payet, A. Kahan & C. Cormier

  2. INSERM, Unité INSERM U845, Centre de Recherche Croissance et Signalisation, Paris Descartes University, Sorbonne Paris Cité, Paris, France

    E. Koumakis & J.-C. Souberbielle

  3. Explorations Fonctionnelles, Hôpital Necker Enfants Malades, APHP, Paris, France

    J.-C. Souberbielle

  4. Chirurgie Générale et Endocrinienne, Hôpital Saint-Louis, APHP, Paris, France

    E. Sarfati

  5. Laboratoire de Biochimie Générale et Spécialisée, Hôpital Cochin, APHP, Paris, France

    D. Borderie

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  1. E. Koumakis
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  2. J.-C. Souberbielle
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  3. J. Payet
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  4. E. Sarfati
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  5. D. Borderie
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  6. A. Kahan
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  7. C. Cormier
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Correspondence to E. Koumakis.

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Koumakis, E., Souberbielle, JC., Payet, J. et al. Individual site-specific bone mineral density gain in normocalcemic primary hyperparathyroidism. Osteoporos Int 25, 1963–1968 (2014). https://doi.org/10.1007/s00198-014-2689-2

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  • DOI: https://doi.org/10.1007/s00198-014-2689-2

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