Skip to main content
Log in

Hepatopathien und Drogenkonsum

Hepatic diseases in the context of drug abuse

  • Leitthema
  • Published:
Rechtsmedizin Aims and scope Submit manuscript

Zusammenfassung

Hepatopathien bei Drogenmissbrauch umfassen ein breites Spektrum an Veränderungen. Die direkten substanzspezifischen Schädigungen der gängigen missbräuchlich konsumierten Drogen sind i. Allg. als gering einzuschätzen. Problematisch sind allerdings der vielfach gleichzeitige Konsum von Alkohol und Infektionen bei i.v.-Missbrauch mit den bekannten Leberschädigungen. Es wird eine Übersicht der wesentlichen Hepatopathien gegeben.

Abstract

Hepatic diseases in the context of drug abuse encompass a broad spectrum of alterations. The direct substance-specific damage caused by the commonly consumed illicit drugs in general seems to be low; however, problematic is the concurrent abuse of alcohol or infections in the context of intravenous abuse, which lead to the known hepatic changes. A survey of the main hepatopathies is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6
Abb. 7
Abb. 8

Literatur

  1. Büttner A, Thieme D, Bidlingmaier M, Madea B (2018) Nebenwirkungen anaboler Substanzen. Rechtsmedizin 28:59–80

    Article  Google Scholar 

  2. Dargan PI, Wood DM (2013) Novel psychoactive substances: classification, pharmacology and toxicology. Academic Press, Elsevier Inc, London, UK

    Google Scholar 

  3. Darke S, Kaye S, Duflou J (2006) Systemic disease among cases of fatal opioid toxicity. Addiction 101:1299–1305

    Article  Google Scholar 

  4. Delaveris GJ, Hoff-Olsen P, Rogde S (2015) Nonnatural deaths among users of illicit drugs: pathological findings and illicit drug abuse stigmata. Am J Forensic Med Pathol 36:44–48

    Article  Google Scholar 

  5. Edland JF (1972) Liver disease in heroin addicts. Hum Pathol 3:75–84

    Article  CAS  Google Scholar 

  6. Ellis AJ, Wendon JA, Portmann B, Williams R (1996) Acute liver damage and ecstasy ingestion. Gut 38:454–458

    Article  CAS  Google Scholar 

  7. Falcato L, Graf S, Bruggmann P (2014) Leberschädigungen und Substanzkonsum. Suchtmed Forsch Prax 16:68–79

    Google Scholar 

  8. Gerlach D (1980) Post-mortem investigations of fatal cases of narcotic addiction. Forensic Sci Int 15:31–39

    Article  CAS  Google Scholar 

  9. Hess C, Maas A, Madea B (2014) „Legal highs“. Chemie, Pharmakologie, Toxikologie und forensische Bedeutung. Rechtsmedizin 24:291–305

    Article  Google Scholar 

  10. Ilić G, Karadžić R, Kostić-Banović L, Antović A (2012) Duration dependent effect of intravenous heroin intake on morphological changes in the liver. Rom J Leg Med 20:13–18

    Article  Google Scholar 

  11. Jones AL, Simpson KJ (1999) Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications. Aliment Pharmacol Ther 13:129–133

    Article  CAS  Google Scholar 

  12. Karch SB, Drummer OH (2016) Karch’s pathology of drug abuse, 5. Aufl. CRC Press, Boca Raton, London, New York

    Google Scholar 

  13. Kielland KB, Delaveris GJ, Rogde S, Eide TJ, Amundsen EJ, Dalgard O (2014) Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: a longitudinal long-term cohort study. J Hepatol 60:260–266

    Article  Google Scholar 

  14. Kringsholm B, Christoffersen P (1982) Liver pathology in fatal drug addiction. Forensic Sci Int 20:141–151

    Article  CAS  Google Scholar 

  15. Kringsholm B, Christoffersen P (1984) Spleen and portal lymph node pathology in fatal drug addiction. Forensic Sci Int 25:233–244

    Article  CAS  Google Scholar 

  16. Kringsholm B, Christoffersen P (1987) Lymph-node and thymus pathology in fatal drug addiction. Forensic Sci Int 34:245–254

    Article  CAS  Google Scholar 

  17. McCruden EA, Hillan KJ, McKay IC, Cassidy MT, Clark JC (1996) Hepatitis virus infection and liver disease in injecting drug users who died suddenly. J Clin Pathol 49:552–555

    Article  CAS  Google Scholar 

  18. Milroy CM, Parai JL (2011) The histopathology of drugs of abuse. Histopathology 59:579–593

    Article  Google Scholar 

  19. Passarino G, Ciccone G, Siragusa R, Tappero P, Mollo F (2005) Histopathological findings in 851 autopsies of drug addicts, with toxicologic and virologic correlations. Am J Forensic Med Pathol 26:106–116

    PubMed  Google Scholar 

  20. Paties C, Peveri V, Falzi G (1987) Liver histopathology in autopsied drug addicts. Forensic Sci Int 35:11–26

    Article  CAS  Google Scholar 

  21. Riordan SM, Williams R (1998) Liver disease due to illicit substance use. Addict Biol 3:47–53

    Article  CAS  Google Scholar 

  22. Stimmel B, Vernace S, Tobias H (1972) Hepatic dysfunction in heroin addicts. The role of alcohol. JAMA 222:811–812

    Article  CAS  Google Scholar 

  23. Tsokos M, Erbersdobler A (2005) Pathology of peliosis. Forensic Sci Int 149:25–33

    Article  Google Scholar 

  24. Trübner K, Polywka S, Püschel K, Laufs R (1991) Hepatitis C in deceased drug addicts. Int J Legal Med 104:251–254

    Article  Google Scholar 

  25. Upreti VV, Eddington ND, Moon K‑H, Song B‑J, Lee IJ (2009) Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”). Toxicol Lett 188:167–172

    Article  CAS  Google Scholar 

  26. Valente MJ, Carvalho F, Bastos MDL, de Pinho PG, Carvalho M (2012) Contribution of oxidative metabolism to cocaine-induced liver and kidney damage. Curr Med Chem 19:5601–5606

    Article  CAS  Google Scholar 

  27. Vitcheva V (2012) Cocaine toxicity and hepatic oxidative stress. Curr Med Chem 19:5677–5682

    Article  CAS  Google Scholar 

  28. Wong GL, Tam YH, Ng CF, Chan AW, Choi PC, Chu WC, Lai PB, Chan HL, Wong VW (2014) Liver injury is common among chronic abusers of ketamine. Clin Gastroenterol Hepatol 12:1759–1762

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Büttner.

Ethics declarations

Interessenkonflikt

A. Büttner gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Büttner, A. Hepatopathien und Drogenkonsum. Rechtsmedizin 29, 185–189 (2019). https://doi.org/10.1007/s00194-019-0310-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00194-019-0310-x

Schlüsselwörter

Keywords

Navigation