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Effects of soy isoflavones on the uterus and urethra of ovariectomized rats

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Abstract

Objective

To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.

Methods

Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 μg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI).

Results

Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF.

Conclusions

Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration.

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Conflicts of interest

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Authors and Affiliations

  1. Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil

    Elaine Travaglia Santos & Maria Dione Dutra Sampaio

  2. Department of Computer Science, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil

    Paulo Roberto Cecon

  3. Department of Morphology, Federal University of São Paulo, São Paulo, Brazil

    Manuel de Jesus Simões

  4. Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil

    Marair Gracio Ferreira Sartori & Manoel João Batista Castello Girão

  5. Department of Gynecology, Federal University of São Paulo, Rua Borges Lagoa, 783, 3º Andar, conjunto 31, Vila Clementino, São Paulo, SP, CEP 04038-031, Brazil

    Elaine Travaglia Santos

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  1. Elaine Travaglia Santos
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  2. Maria Dione Dutra Sampaio
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  3. Paulo Roberto Cecon
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  5. Marair Gracio Ferreira Sartori
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  6. Manoel João Batista Castello Girão
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Correspondence to Elaine Travaglia Santos.

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Santos, E.T., Sampaio, M.D.D., Cecon, P.R. et al. Effects of soy isoflavones on the uterus and urethra of ovariectomized rats. Int Urogynecol J 21, 111–116 (2010). https://doi.org/10.1007/s00192-009-0995-6

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  • DOI: https://doi.org/10.1007/s00192-009-0995-6

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