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Development of composite porous scaffolds based on poly(lactide-co-glycolide)/nano-hydroxyapatite via selective laser sintering

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Abstract

Poly(lactide-co-glycolide) (PLGA)/nano-hydroxyapatite (nano-HAP) composite porous scaffolds with well-controlled pore architectures as well as high exposure of the bioactive ceramics to the scaffold surface were fabricated via selective laser sintering. Neat PLGA and the composite of PLGA/nano-HAP were used to obtain suitable process parameters. The effects of nano-HAP content on the microstructure and mechanical properties were investigated. The testing results showed that the compressive strength and modulus of the scaffolds were highly enhanced when the nano-HAP content reached from 0 to 20 wt%, while the mechanical properties experienced a sharp dropped with the nano-HAP content further increased. This might be due to the large reduction in polymer which decreased the interface bond strength between particles. It suggests that the introduction of nano-HAP as a reinforcing phase can improve the mechanical properties of the polymer porous scaffolds. The novel developed scaffolds may serve as a three-dimensional bone substrate in tissue engineering.

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Authors and Affiliations

  1. State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, People’s Republic of China, 410083

    Cijun Shuai & Bo Yang

  2. Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA

    Cijun Shuai

  3. Cancer Research Institute, Central South University, Changsha, People’s Republic of China, 410078

    Shuping Peng & Zheng Li

Authors
  1. Cijun Shuai
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  2. Bo Yang
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  3. Shuping Peng
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  4. Zheng Li
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Correspondence to Shuping Peng or Zheng Li.

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Shuai, C., Yang, B., Peng, S. et al. Development of composite porous scaffolds based on poly(lactide-co-glycolide)/nano-hydroxyapatite via selective laser sintering. Int J Adv Manuf Technol 69, 51–57 (2013). https://doi.org/10.1007/s00170-013-5001-2

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  • DOI: https://doi.org/10.1007/s00170-013-5001-2

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