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Multilayer scaffolds in orthopaedic tissue engineering

  • Experimental Study
  • Published:
Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration.

Methods

Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces.

Results

In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications.

Conclusions

Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.

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Author information

Authors and Affiliations

  1. Sports Medicine and Shoulder Service, Hospital for Special Surgery, 525 East 71st Street, New York, NY, 10021, USA

    Kivanc Atesok & Scott A. Rodeo

  2. Department of Orthopaedics and Traumatology, Hacettepe University School of Medicine, 06100, Sihhiye, Ankara, Turkey

    M. Nedim Doral

  3. Department of Orthopaedics, Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg University, 431 80, Molndal, Sweden

    Jon Karlsson

  4. Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 303 2nd Avenue, New York, NY, 10003, USA

    Kenneth A. Egol

  5. Department of Periodontology and Implant Dentistry, New York University College of Dentistry, 345 east 24th street Room 804s, New York, NY, 10010, USA

    Paulo G. Coelho

  6. Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, 650-0017, Japan

    Tomoyuki Matsumoto

  7. Orthopaedic Surgery Service, Keller Army Hospital, 900 Washington Rd, West Point, New York, NY, 10996, USA

    Brett D. Owens

  8. Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minamimi-ku, Hiroshima, 734-8551, Japan

    Mitsuo Ochi

  9. Department of Orthopaedic Surgery, University of North Carolina, Chapel Hill, NC, USA

    Shepard R. Hurwitz

  10. American Board of Orthopaedic Surgery, 400 Silver Cedar Court, Chapel Hill, NC, 27514, USA

    Shepard R. Hurwitz

  11. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA

    Anthony Atala

  12. Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 1011, Pittsburgh, PA, 15213, USA

    Freddie H. Fu

  13. Department of Biomedical Engineering, Columbia University, New York, NY, 10016, USA

    Helen H. Lu

  14. Center for Musculoskeletal Care, NYU Hospital for Joint Diseases, 333 east 38th street, New York, NY, 10016, USA

    Laith M. Jazrawi & Amaury Martinez

Authors
  1. Kivanc Atesok
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  2. M. Nedim Doral
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  3. Jon Karlsson
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  4. Kenneth A. Egol
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  5. Laith M. Jazrawi
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  6. Paulo G. Coelho
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  7. Amaury Martinez
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  8. Tomoyuki Matsumoto
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  9. Brett D. Owens
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  10. Mitsuo Ochi
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  11. Shepard R. Hurwitz
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  12. Anthony Atala
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  13. Freddie H. Fu
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  14. Helen H. Lu
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  15. Scott A. Rodeo
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Corresponding author

Correspondence to Scott A. Rodeo.

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Atesok, K., Doral, M.N., Karlsson, J. et al. Multilayer scaffolds in orthopaedic tissue engineering. Knee Surg Sports Traumatol Arthrosc 24, 2365–2373 (2016). https://doi.org/10.1007/s00167-014-3453-z

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  • DOI: https://doi.org/10.1007/s00167-014-3453-z

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