Skip to main content

Advertisement

SpringerLink
Log in

Long-term outcomes of patients supported with extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis

  • Systematic Review
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Background

Extracorporeal membrane oxygenation (ECMO) is increasingly used to support patients with severe acute respiratory distress syndrome (ARDS). The impact of ECMO on long-term outcomes of patients with severe ARDS is unclear.

Methods

We searched electronic databases from inception to January 17th 2023. We selected clinical trials and observational studies reporting on long-term outcomes of patients supported with ECMO for ARDS. Health-related quality of life (HRQoL) was the primary outcome. Secondary outcomes included cognitive function, mental health, functional status, respiratory symptoms, and return to work.

Results

Of the 7126 screened citations, 1 randomized clinical trial and 31 observational studies were included, of which 7 compared conventional mechanical ventilation (CMV) and ECMO. Overall quality of studies of the included studies was limited, with the majority being either low (45%) or fair (32%) quality. There was no significant difference in HRQoL measured with the SF-36 score between ECMO and CMV patients (physical component score [PCS]: mean difference 3.91 (− 6.22 to 14.05), mental component score [MCS] mean difference 1.33 (− 3.93 to 6.60)). There was no difference between cognitive function, mental health, functional status, and respiratory symptoms between ECMO and CMV, but data available for comparison were limited. There were high rates of disability for ECMO survivors with 49% of patients returning to work and 23% needing assistance at home on follow-up.

Conclusion

Survivors of ECMO for ARDS experience significant disability in multiple domains. Further studies are needed to examine the effect of ECMO on long-term outcomes of patients compared to CMV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. ARDS Definition Task Force (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307(123):2526–2533

    Google Scholar 

  2. Bellani G, Laffey J, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley D, Ranieri M, Rubenfeld G, Thompson B, Wrigge H, Slutsky A, Pesenti A (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315(18):788–800

    Article  CAS  PubMed  Google Scholar 

  3. Herridge M, Tansey C, Matté A, Tomlinson G, Diaz-Granados A, Cooper A, Guest C, Mazer C, Mehta S, Stewart T, Kudlow P, Cook D, Slutsky A, Cheung A, Herridge M (2011) Functional disability 5 years after acute respiratory distress syndrome. New Eng J Med 364(114):1293–1304

    Article  CAS  PubMed  Google Scholar 

  4. Herridge M, Cheung A, Tansey C, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper A, Guest C, Mazer C, Mehta S, Stewart T, Barr A, Cook D, Slutsky A (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. New Eng J Med 348(18):683–693

    Article  PubMed  Google Scholar 

  5. Hopkins R, Key C, Suchyta M, Weaver L, Orme JJ (2010) Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry 32(12):147–155

    Article  PubMed  Google Scholar 

  6. Mikkelsen M, Christie J, Lanken P, Biester R, Thompson B, Bellamy S, Localio A, Demissie E, Hopkins R, Angus D (2012) The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 185(112):1307–1315

    PubMed  PubMed Central  Google Scholar 

  7. Stokes E, Zambrano L, Anderson K, Marder E, Raz K, El Burai Felix S, Tie Y, Fullerton K (2020) Coronavirus Disease 2019 case surveillance - United States, January 22–May 30, 2020. MMWR Morb Mortal Wkly Rep 69(124):759–765

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kho M, Rewa O, Boyd J, Choong K, Stewart G, Herridge M (2022) Outcomes of critically ill COVID-19 survivors and caregivers: a case study-centred narrative review. Can J Anesthesia 69(15):630–643

    Article  CAS  Google Scholar 

  9. ELSO (2023) ECLS Registry Report 2022 - International Summary. Available: https://www.elso.org/registry/internationalsummaryandreports/internationalsummary.aspx

  10. Combes A, Peek G, Hajage D, Hardy P, Abrams D, Schmidt M, Dechartres A, Elbourne D (2020) ECMO for severe ARDS: systematic review and individual patient data meta-analysis. Intensive Care Med. New Eng J Med 46(111):2048–2057

    CAS  Google Scholar 

  11. Ramanathan K, Shekar K, Ling R, Barbaro R, Wong S, Tan C, Rochwerg B, Fernando S, Takeda S, MacLaren G, Fan E, Brodie D (2021) Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Crit Care 25(11):211

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wilcox M, Jaramillo-Rocha V, Hodgson C, Taglione M, Ferguson N, Fan E (2020) Long-term quality of life after extracorporeal membrane oxygenation in ARDS survivors: systematic review and meta-analysis. J Intensive Care Med 35(13):233–243

    Article  PubMed  Google Scholar 

  13. Higgins J and Green S (2021) Cochrane handbook for systematic review of interventions. Available: https://training.cochrane.org/handbook/current

  14. Higgins J, Lasserson T, Chandler J, Tovey D and Churchill R (2016) Methodological expectations of cochrane intervention reviews. Available: https://community.cochrane.org/mecir-manual

  15. Page M, Moher D, Bossuyt P, Boutron I, TC H, Mulrow C et al (2021) PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic review. BMJ 372

  16. Rethlefsen M, Kirtley S, Waffenschmidt S, Ayala A, Moher D, Page M, Koffel J, P. group (2021) PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews. Syst Rev 10(11):39

    Article  PubMed  PubMed Central  Google Scholar 

  17. McGowan J, Sampson M, Salzwedel D, Cogo E, Foerster V, L. C (2016) PRESS peer review of electronic search strategies: 2015 guideline statement. J Clin Epidemiol 75:40–46

    Article  PubMed  Google Scholar 

  18. Grossetta Nardini N and Wang L (2015) The Yale MeSH analyzer. Available: http://mesh.med.yale.edu/. [Accessed Nov 2022]

  19. Veritas Health Information (2023) Covidence. Available: www.covidence.org. [Accessed 2023]

  20. Bertini P, Guarracino F, Falcone M, Nardelli P, Landoni G, Nocci M, Paternoster G (2022) ECMO in COVID-19 patients: a systematic review and meta-analysis. J Cardiothorac VasC Anesth 36(18):2700–2706

    Article  CAS  PubMed  Google Scholar 

  21. Hodgson C, Higgins A, Bailey M, Anderson S, Bernard S, Fulcher B, Koe D, Linke N, Board J, Brodie D, Buhr H, Burrell A, Cooper D, Fan E, Fraser J, Gattas D, Hopper I, Huckson EA (2022) Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study. Lancet Respir Med 10(111):1038–1048

    Article  PubMed  Google Scholar 

  22. Burrell A, Andrew Udy A, Pellegrino V, Hodgson C (2022) Six-month outcomes following venovenous ECMO for severe COVID-19 and viral pneumonitis: 2019–2020 Australian experience. Crit Care Resusc 24(11):83–86

    PubMed  Google Scholar 

  23. Wells G, Wells G, Shea B, Shea B, O'Connell D, Peterson J, Welch Losos M, Tugwell P, Ga S, Zello G and Petersen J (2014) The Newcastle-Ottawa Scale (NOS) for assessing the quality of Nonrandomised studies in meta-analyses. Ottawa

  24. Sterne J, Savović J, Page M, Elbers R, Blencowe N, Boutron I, Cates C, Cheng H, Corbett M, Eldridge S, Hernán M, Hopewell S, Hróbjartsson A, Junqueira D, Jüni P, Kirkham J, Lasserson T, Li T et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898

    Article  PubMed  Google Scholar 

  25. T. C. Collaboration (2020) Review manager (RevMan) Version 5.4. Oxford

  26. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(111):1539–1558

    Article  PubMed  Google Scholar 

  27. Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Halanany M, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D (2009) Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. The Lancet 374(19698):1351–1363

    Article  Google Scholar 

  28. Boyle A, McDowell C, Agus A, Logan D, Stewart J, Jackson C, Mills J, McNamee J, McAuley D (2022) Acute hypoxaemic respiratory failure after treatment with lower tidal volume ventilation facilitated by extracorporeal carbon. Thorax. https://doi.org/10.1136/thorax-2022-218874

    Article  PubMed  Google Scholar 

  29. Chommeloux J, Valentin S, Winiszewski H, Adda M, Chambrun M, Moyon Q, Mathian A, Capellier G, Guervilly C, Levy B, Jaquet P, Sonneville R, Voiriot G, Demoule A, Boussouar S, Painvin B, Lebreton G, Combes A et al (2022) One-year mental and physical health assessment in survivors after extracorporeal membrane oxygenation for COVID-19–related acute respiratory distress syndrome. Am J Respir Crit Care Med 207(12):150–159

    PubMed Central  Google Scholar 

  30. Enger T, Philipp A, Lubnow M, Fischer M, Camboni D, Lunz D, Bein T, Müller T (2017) Long-term survival in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation. Crit Care Med 45(110):1718–1725

    Article  PubMed  Google Scholar 

  31. Galazzi A, Brambilla A, Grasselli G, Pesenti A, Fumagalli R, Lucchini A (2018) Quality of life of adult survivors after extra corporeal membrane oxygenation (ECMO): a quantitative study. Dimen Crit Care Nurs 37(11):12–17

    Article  Google Scholar 

  32. George T, Sheasby J, Shih E, Erwin G, Taylor J, Curry M, Lilly J, Vaquera K, Harness-Brumley C, Myers D, Michael DiMaio J (2022) Intermediate-term survival and functional outcomes of COVID-19 extracorporeal membrane oxygenation patients. J Cardiac Surg 37(14):789–794

    Article  Google Scholar 

  33. Grasselli G, Scaravilli V, Tubiolo D, Russo R, Crimella F, Bichi F, Corinna Morlacchi L, Scotti E, Patrini L, Gattinoni L, Pesenti A, Chiumello D (2019) Quality of life and lung function in survivors of extracorporeal membrane oxygenation for acute respiratory distress syndrome. Anesthesiology 130(14):572–580

    Article  CAS  PubMed  Google Scholar 

  34. Gray E, Forrest P, Southwood T, Totaro R, Plunkett B, Torzillo P (2021) Long-term outcomes of adults with acute respiratory failure treated with veno-venous extracorporeal membrane oxygenation. Anaesthesia Intensive Care 9(16):477–485

    Article  Google Scholar 

  35. Gribensk A, Schneider A, Gallaher J, Reid T, Kindell D, Charles A, Raff L (2022) Posthospitalization outcomes after extracorporeal membrane oxygenation (ECMO) for COVID-19. Surgery 172(11):466–469

    Article  PubMed  Google Scholar 

  36. Hodgson C, Hayes K, Everard T, Nichol A, Davies A, Bailey M, Tuxen D, Cooper D, Pellegrino V (2012) Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia. Crit Care 16(15):R202

    Article  PubMed  PubMed Central  Google Scholar 

  37. Kanji H, Chouldechova A, Harris-Fox S, Ronco J, O’Dea E, Harvey C, Shuster C, Thiara S, Peek G (2021) Quality of life and functional status of patients treated with venovenous extracorporeal membrane oxygenation at 6 months. Jf Crit Care 66:26–30

    Article  CAS  Google Scholar 

  38. Knoch M, Kukule I, Müller E, Höltermann W (1992) Lungenfunktion ein Jahr nach extrakorporalem Lungenersatz (ELA) [lung function one year after extracorporeal lung assist (ELA). Long-term follow-up of patients with most severe adult respiratory distress syndrome]. Anästhesiol Intensivmed Notfallmed Schmerzther 27(18):477–482

    Article  CAS  PubMed  Google Scholar 

  39. Lin W, Chang Y, Weng L, Tsai F, Huang H, Yeh S, Chen K (2022) Post-discharge depression status for survivors of extracorporeal membrane oxygenation (ECMO): comparison of Veno-Venous ECMO and Veno-Arterial ECMO. Int J Environ Res Public Health 19(16):3333

    Article  PubMed  PubMed Central  Google Scholar 

  40. Linden V, Lidegran M, Frisen G, Dahlgren P, Frenckner BP, Larsen F (2009) ECMO in ARDS: a long-term follow-up study regarding pulmonary morphology and function and health-related quality of life. Acta Anaesthesiol Scand 53(14):489–495

    Article  CAS  PubMed  Google Scholar 

  41. Lorusso R, De Piero M, Di Mauro MSM, Folliguet T, Taccone F, Camporota L, Swol J, Wiedemann D, Belliato M, Broman L, Kassif VAY, Scandroglio A, Fanelli V, Gaudard P, Ledot S et al (2023) In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study. Lancet Respir Med 11(12):151–162

    Article  PubMed  Google Scholar 

  42. Luyt C, Combes A, Becquemin M, Beigelman-Aubry C, Hatem S, Brun A, Zraik N, Carrat F, Grenier P, Richard J, Mercat A, Brochard L, Brun-Buisson C, Chastre J (2012) Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS. Chest 142(13):583–592

    Article  CAS  PubMed  Google Scholar 

  43. Marsh L, Leach R, Blane J, Daly K, Barrett N, Slack A, Kopelman M (2021) Long-term cognitive and psychiatric outcomes of acute respiratory distress syndrome managed with Extracorporeal Membrane Oxygenation. Respir Med 1183:106419

    Article  Google Scholar 

  44. McDonald M, Sandsmark D, Palakshappa J, Mikkelsen M, Anderson B, Gutsche J (2019) Long-term outcomes after extracorporeal life support for acute respiratory failure. J Cardiothorac Vasc Anesth 33(11):72–79

    Article  PubMed  Google Scholar 

  45. Mostafa ATC, Mckie M, Fowles J, Parmar J, Vuylsteke A (2022) Predictors of health-related quality of life in patients undergoing extracorporeal membrane oxygenation for acute severe respiratory failure. J Intensive Care Soc. https://doi.org/10.1177/17511437221111639

    Article  PubMed  PubMed Central  Google Scholar 

  46. O’Brien SG, Carton EG, Fealy GM (2020) Long-term health-related quality of life after venovenous extracorporeal membrane oxygenation. ASAIO J 66(15):580–585

    Article  PubMed  Google Scholar 

  47. Provaznik Z, Philipp A, Müller T, Kostiantyn K, Lunz D, Schmid C, Floerchinger B (2023) Outcome after veno-venous extracorporeal membrane oxygenation in elderly compared to younger patients: a 14-year retrospective observational study. Artif Organs 47(15):882–890

    Article  CAS  PubMed  Google Scholar 

  48. Rajajee V, Fung C, Seagly K, Park P, Raghavendran K, Machado-Aranda D, Scott J, Delano M, Abou El Ela A, Haft J, Williamson C, McSparron J, Blank R, Napolitano L (2021) One-year functional, cognitive, and psychological outcomes following the use of extracorporeal membrane oxygenation in coronavirus disease 2019: a prospective study. Crit Care Explor 3(19):e0537

    Article  PubMed  PubMed Central  Google Scholar 

  49. Rilinger J, Krötzsch K, Bemtgen X, Jäckel M, Zotzmann V, Lang C, Kaier K, Duerschmied D, Supady A, Bode C, Staudacher D, Wengenmayer T (2021) Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support. Crit Care 25(11):410

    Article  PubMed  PubMed Central  Google Scholar 

  50. Sanfilippo F, Ippolito M, Santonocito C, Martucci G, Carollo T, Bertani A, Vitulo P, Pilato M, Panarello G, Giarratano A, Arcadipane A (2019) Long-term functional and psychological recovery in a population of acute respiratory distress syndrome patients treated with VV-ECMO and in their caregivers. Minerva Anestesiol 85(19):971–980

    PubMed  Google Scholar 

  51. Schmidt M, Zogheib, Rozé H, Repesse X, Lebreton G, Luyt C, Trouillet J, Bréchot N, Nieszkowska A, Dupont H, Ouattara A, Leprince P, Chastre J, Combes A (2013) The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med 39(10):1704–1713

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Stoll C, Haller M, Briegel J, Meier M, Manert W, Hummel T, Heyduck M, Lenhart A, Polasek J, Bullinger M, Schelling G (1998) Gesundheitsbezogene Lebensqualität Langzeitüberlebende, erwachsene Patienten mit ARDS nach extrakorporaler Membranoxygenation (ECMO). Anaesthesist 47(11):24–29

    Article  CAS  PubMed  Google Scholar 

  53. Sylvestre A, Adda M, Maltese F, Lannelongue A, Daviet F, Parzy G, Coiffard B, Roch A, Loundou A, Baumstarck K, Papazian L (2019) Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients. Ann Intensive Care 9(11):82

    Article  PubMed  PubMed Central  Google Scholar 

  54. Wang Z, Li T, Wang C, Xu L, Gao X (2017) Assessment of 1-year outcomes in survivors of severe acute respiratory distress syndrome receiving extracorporeal membrane oxygenation or mechanical ventilation: a prospective observational study. Chin Med J 130(110):1161–1168

    Article  PubMed  PubMed Central  Google Scholar 

  55. von Bahr V, Kalzén H, Frenckner B, Hultman J, Frisén K, Lidegran M, Diaz S, Malfertheiner M, Millar J, Dobrosavljevic T, Eksborg S, Holzgraefe B (2019) Long-term pulmonary function and quality of life in adults after extracorporeal membrane oxygenation for respiratory failure. Perfusion 34(11-Suppl):49–57

    Article  Google Scholar 

  56. von Bahr V, Kalzén H, Hultman J, Frenckner B, Andersson C, Mosskin M, Eksborg S, Holzgraefe B (2018) Long-term cognitive outcome and brain imaging in adults after extracorporeal membrane oxygenation. Crit Care Med 46(15):e351–e358

    Article  Google Scholar 

  57. Üstün T, Kostanjsek N, Chatterji S, Rehm J (2010) Measuring health and disability: manual for WHO disability assessment schedule WHODAS 2.0. World Health Organization

    Google Scholar 

  58. Oken M, Creech R, Tormey D, Horton J, Davis T, McFadden E, Carbone P (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5(16):649–655

    Article  CAS  PubMed  Google Scholar 

  59. Hopman W, Towheed T, Anastassiades T, Tenenhouse A, Poliquin S, Berger C, Joseph L, Brown J, Murray T, Adachi J, Hanley D, Papadimitropoulos E (2000) Canadian normative data for the SF-36 health survey. Can Med Assoc J 163(13):265–271

    CAS  Google Scholar 

  60. Alberta PROMs & EQ-5D Research & Support Unit (APERSU) (2018) Alberta Population Norms for EQ-5D-5L. Available: https://apersu-uat.srv.ualberta.ca/about-eq-5d/norms/. [Accessed 2023]

  61. Hopkins R, Weaver L, Collingridge D, Parkinson R, Chan K, Orme JJ (2005) Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 171(14):340–347

    Article  PubMed  Google Scholar 

  62. Cheung A, Tansey C, Tomlinson G, Diaz-Granados N, Matté A, Barr A, Mehta S, Mazer C, Guest C, Stewart T, Al-Saidi F, Cooper A, Cook D, Slutsky A, Herridge MS (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174(15):538–544

    Article  PubMed  Google Scholar 

  63. Sasannejad C, Ely E, Lahiri S (2019) Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care 23:352

    Article  PubMed  PubMed Central  Google Scholar 

  64. Burrell A, Lubnow M, Enger T, Nanjayya V, Philipp A, Malfertheiner M, Lunz D, Bein T, Pellegrino V, Müller T (2017) The impact of venovenous extracorporeal membrane oxygenation on cytokine levels in patients with severe acute respiratory distress syndrome: a prospective, observational study. Crit Care Resusc 19(1 Suppl 1):37–44

    CAS  PubMed  Google Scholar 

  65. Nigoghossian C, Dzierba A, Etheridge J, Roberts R, Muir J, Brodie D, Schumaker G, Bacchetta M, Ruthazer R, Devlin J (2016) Effect of extracorporeal membrane oxygenation use on sedative requirements in patients with severe acute respiratory distress syndrome. Pharmacotherapy 36(16):607–616

    Article  PubMed  Google Scholar 

  66. von Stillfried S, Bülow R, Röhrig R, Meybohm P, Boor P, D. C. German Registry of COVID-19 Autopsies (DeRegCOVID) (2022) Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report. Crit Care 26(11):83

    Article  Google Scholar 

  67. Davydow D, Zatzick D, Hough C, Katon W (2013) A longitudinal investigation of posttraumatic stress and depressive symptoms over the course of the year following medical-surgical intensive care unit admission. Gen Hosp Psychiatry 35(13):226–232

    Article  PubMed  PubMed Central  Google Scholar 

  68. Geense W, Zegers M, Peters M, Ewalds E, Simons K, Vermeulen H, van der Hoeven J, van den Boogaard M (2021) New physical, mental, and cognitive problems 1 year after ICU admission: a prospective multicenter study. Am J Respir Crit Care Med 203(112):1512–1521

    Article  PubMed  Google Scholar 

  69. Huang M, Parker A, Bienvenu O, Dinglas V, Colantuoni E, Hopkins R, Needham D, N. H. L. a. B. I. A. R. D. S. N. National Institutes of Health (2016) Psychiatric symptoms in acute respiratory distress syndrome survivors: a 1-year national multicenter study. Crit Care Med 44(15):954–965

    Article  PubMed  PubMed Central  Google Scholar 

  70. Latronico N, Peli E, Calza S, Rodella F, Novelli M, Cella A, Marshall J, Needham D, Rasulo F, Piva S, L. Investigators (2022) Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS. Thorax 77(13):300–303

    Article  PubMed  Google Scholar 

  71. Piva S, Pozzi M, Bellani G, Peli E, Gitti N, Lucchini A, Bertoni M, Goffi A, Marshall J, Calza S, Rasulo F, Foti G, Latronico N, L. Investigators (2023) Long-term physical impairments in survivors of COVID-19-associated ARDS compared with classic ARDS: a two-center study. J Crit Care 76:154285

    Article  PubMed  Google Scholar 

  72. Hodgson C, Higgins A, Bailey M, Mather A, Beach L, Bellomo R, Bissett B, Boden I, Bradley S, Burrell A, Cooper D, Fulcher B, Haines K, Hodgson I, Hopkins J, Jones A, Lane S et al (2022) Comparison of 6-month outcomes of survivors of COVID-19 versus non-COVID-19 critical illness. Am J Respir Crit Care Med 205(110):1159–1168

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Bienvenu O, Friedman L, Colantuoni E, Dinglas V, Sepulveda K, Mendez-Tellez P, Shanholz C, Pronovost P, Needham D (2018) Psychiatric symptoms after acute respiratory distress syndrome: a 5-year longitudinal study. Intensive Care Med 44(11):38–47

    Article  PubMed  Google Scholar 

  74. Hodgson C, Burrell A, Engeler D, Pellegrino V, Brodie D, Fan E, Network IE (2019) Core outcome measures for research in critically ill patients receiving extracorporeal membrane oxygenation for acute respiratory or cardiac failure: an international, multidisciplinary, modified Delphi consensus study. Crit Care Med 47(111):1557–1563

    Article  PubMed  Google Scholar 

  75. Allen DW, Ma B (2017) Risk prediction models for contrast-induced acute kidney injury accompanying cardiac catheterization: systematic review and meta-analysis. Can J Cardiol 133:724–736

    Article  Google Scholar 

  76. Banavasi H, Nguyen P, Osman H, Soubani A (2021) Management of ARDS—what works and what does not. Am J Med Sci 362(11):13–23

    Article  PubMed  Google Scholar 

  77. Aoyama H, Uchida K, Aoyama K, Pechlivanoglou P, Englesakis M, Yamada Y, Fan E (2019) Assessment of therapeutic interventions and lung protective ventilation in patients with moderate to severe acute respiratory distress syndrome: a systematic review and network meta-analysis. JAMA Netw Open 2(17):e198116

    Article  PubMed  PubMed Central  Google Scholar 

  78. Pfoh E, Chan K, Dinglas V, Cuthbertson B, Elliott D, Porter R, Bienvenu O, Hopkins R, Needham D (2016) The SF-36 offers a strong measure of mental health symptoms in survivors of acute respiratory failure a tri-national analysis. Ann Am Thorac Soc 13(18):1343–1350

    Article  PubMed  PubMed Central  Google Scholar 

  79. Tipping C, Young P, Romero L, Saxena M, Dulhunty J, Hodgson C (2012) A systematic review of measurements of physical function in critically ill adults. Crit Care Resusc 14(14):302–311

    PubMed  Google Scholar 

  80. Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M et al (2022) The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. Available: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.

  81. Ware JJ, Sherbourne C (1992) The MOS 36-item short-form health survey (SF-36). Edical Care 30(16):473–483

    Article  Google Scholar 

Download references

Funding

No specific funding was provided for this review.

Author information

Authors and Affiliations

  1. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

    Julien Turgeon, Varsha Venkatamaran & Eddy Fan

  2. Institut Universitaire de Cardiologie et de Pneumologie de Québec, 2725 Chemin Ste-Foy, Québec, Qc, G1V 4G5, Canada

    Julien Turgeon

  3. Department of Medicine, University Health Network and Sinai Health System, Toronto, Canada

    Eddy Fan

  4. Department of Medicine, University of Toronto, Toronto, Canada

    Eddy Fan

  5. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada

    Eddy Fan

  6. Library and Information Services, University Health Network, Toronto, Canada

    Marina Englesakis

Authors
  1. Julien Turgeon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Varsha Venkatamaran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marina Englesakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Eddy Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

JT and EF designed the review. ME designed and completed the search strategy. JT and VV selected articles. JT extracted data and wrote the draft of the manuscript. All authors reviewed and approved the manuscript.

Corresponding author

Correspondence to Julien Turgeon.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Turgeon, J., Venkatamaran, V., Englesakis, M. et al. Long-term outcomes of patients supported with extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Intensive Care Med 50, 350–370 (2024). https://doi.org/10.1007/s00134-023-07301-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-023-07301-7

Keywords

Search

Navigation