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Understanding paracetamol-induced liver failure

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Fig. 1

Abbreviations

ALF:

Acute liver failure

NAC:

N-Acetylcysteine

NAPQI:

N-Acetyl-p-benzoquinone imine

References

  1. Prescott LF (1979) Paracetamol poisoning. Prevention of liver damage. Med Chir Dig 8:391–393

    CAS  PubMed  Google Scholar 

  2. Khalid SK, Lane J, Navarro V, Garcia-Tsao G (2009) Use of over-the-counter analgesics is not associated with acute decompensation in patients with cirrhosis. Clin Gastroenterol Hepatol 7(9):994–999

    Article  PubMed Central  PubMed  Google Scholar 

  3. Prescott LF (1996) Hepatotoxicity. In: Prescott LF (ed) Paracetamol (acetaminophen): a critical bibliographic review. Taylor & Francis, London, pp 285–351

    Google Scholar 

  4. Clemmesen JO, Kondrup J, Ott P (2000) Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. Gastroenterology 118(6):1131–1139

    Article  CAS  PubMed  Google Scholar 

  5. Cordoba J, Ventura-Cots M, Simón-Talero M, Amorós A, Pavesi M, Vilstrup H, Angeli P, Domenicali M, Ginés P, Bernardi M, Arroyo V, CANONIC Study Investigators of the EASL-CLIF Consortium (2014) Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF). J Hepatol 60(2):275–281

    Article  PubMed  Google Scholar 

  6. Bernal W, Wendon J (2013) Acute liver failure. N Engl J Med 369(26):2525–2534

    Article  CAS  PubMed  Google Scholar 

  7. Schmidt LE, Larsen FS (2006) Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med 34(2):337–343

    Article  PubMed  Google Scholar 

  8. Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P (1999) Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29(3):648–653

    Article  CAS  PubMed  Google Scholar 

  9. Shawcross DL, Wendon JA (2012) The neurological manifestations of acute liver failure. Neurochem Int 60(7):662–671

    Article  CAS  PubMed  Google Scholar 

  10. Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O’Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M (2013) Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure. Hepatology 59(4):1564–1576. doi:10.1002/hep.26933

    Article  Google Scholar 

  11. Stravitz RT, Lisman T, Luketic VA et al (2012) Minimal effects of acute liver injury/acute liver failure on hemostasis as assessed by thromboelastography. J Hepatol 56:129–136

    Article  PubMed  Google Scholar 

  12. Simpson KJ, Bates CM, Henderson NC et al (2009) The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies. Liver Transpl 15:600–609

    Article  PubMed  Google Scholar 

  13. Harrison PM, Keays R, Bray GP, Alexander GJ, Williams R (1990) Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of N-acetylcysteine. Lancet 335(8705):1572–1573

    Article  CAS  PubMed  Google Scholar 

  14. Schmidt LE, Wang LP, Hansen BA, Larsen FS (2003) Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: a prospective controlled trial. Liver Transpl 9(3):290–297

    Article  PubMed  Google Scholar 

  15. Saliba F, Camus C, Durand F, Mathurin P, Letierce A, Delafosse B, Barange K, Perrigault PF, Belnard M, Ichaï P, Samuel D (2013) Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial. Ann Intern Med 159(8):522–531

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, A-2121, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark

    Fin Stolze Larsen

  2. Institute of Liver Studies, Kings College Hospital, London, UK

    Julia Wendon

Authors
  1. Fin Stolze Larsen
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  2. Julia Wendon
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Corresponding author

Correspondence to Fin Stolze Larsen.

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Larsen, F.S., Wendon, J. Understanding paracetamol-induced liver failure. Intensive Care Med 40, 888–890 (2014). https://doi.org/10.1007/s00134-014-3293-9

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  • DOI: https://doi.org/10.1007/s00134-014-3293-9

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