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Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study

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Abstract

Purpose

To determine the incidence of and risk factors for adverse cardiac events during catecholamine vasopressor therapy in surgical intensive care unit patients with cardiovascular failure.

Methods

The occurrence of any of seven predefined adverse cardiac events (prolonged elevated heart rate, tachyarrhythmia, myocardial cell damage, acute cardiac arrest or death, pulmonary hypertension-induced right heart dysfunction, reduction of systemic blood flow) was prospectively recorded during catecholamine vasopressor therapy lasting at least 12 h.

Results

Fifty-four of 112 study patients developed a total of 114 adverse cardiac events, an incidence of 48.2 % (95 % CI, 38.8–57.6 %). New-onset tachyarrhythmia (49.1 %), prolonged elevated heart rate (23.7 %), and myocardial cell damage (17.5 %) occurred most frequently. Aside from chronic liver diseases, factors independently associated with the occurrence of adverse cardiac events included need for renal replacement therapy, disease severity (assessed by the Simplified Acute Physiology Score II), number of catecholamine vasopressors (OR, 1.73; 95 % CI, 1.08–2.77; p = 0.02) and duration of catecholamine vasopressor therapy (OR, 1.01; 95 % CI, 1–1.01; p = 0.002). Patients developing adverse cardiac events were on catecholamine vasopressors (p < 0.001) and mechanical ventilation (p < 0.001) for longer and had longer intensive care unit stays (p < 0.001) and greater mortality (25.9 vs. 1.7 %; p < 0.001) than patients who did not.

Conclusions

Adverse cardiac events occurred in 48.2 % of surgical intensive care unit patients with cardiovascular failure and were related to morbidity and mortality. The extent and duration of catecholamine vasopressor therapy were independently associated with and may contribute to the pathogenesis of adverse cardiac events.

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Conflicts of interest

The authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

    Christian A. Schmittinger & Christian Torgersen

  2. Department of Anaesthesiology, Surgical Intensive Care Medicine, and Rescue Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland

    Christian A. Schmittinger

  3. Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria

    Christian Torgersen, Günter Luckner, Daniel C. H. Schröder & Ingo Lorenz

  4. Department of Anaesthesiology, Perioperative and Intensive Care Medicine, Salzburg General Hospital, Paracelsus Private Medical University, Salzburg, Austria

    Martin W. Dünser

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  1. Christian A. Schmittinger
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  2. Christian Torgersen
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  3. Günter Luckner
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  4. Daniel C. H. Schröder
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  5. Ingo Lorenz
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  6. Martin W. Dünser
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Correspondence to Christian A. Schmittinger.

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Schmittinger, C.A., Torgersen, C., Luckner, G. et al. Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study. Intensive Care Med 38, 950–958 (2012). https://doi.org/10.1007/s00134-012-2531-2

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  • DOI: https://doi.org/10.1007/s00134-012-2531-2

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