Skip to main content
SpringerLink
Log in

Kastrationsresistentes Prostatakarzinom

Chirurgische und strahlentherapeutische Therapieoptionen

Castration-resistant prostate cancer

Surgical and radio-oncological therapeutic options

  • Leitthema
  • Published:
Der Urologe Aims and scope Submit manuscript

Zusammenfassung

Die Therapie des kastrationsrefraktären Prostatakarzinoms stellt eine Herausforderung an den behandelnden Arzt dar. Aufgrund des polysymptomatischen Verlaufs steht die multidisziplinäre Zusammenarbeit verschiedener Fachrichtungen (Urologie, Strahlentherapie, Medizinische Onkologie, Palliativmedizin, Orthopädie, Neurochirurgie) im Mittelpunkt. Es stehen verschiedene chirurgische und strahlentherapeutische palliative Therapieoptionen zur Verfügung, welche zu unterschiedlichen Zeitpunkten dieser Erkrankung eine sinnvolle Ergänzung darstellen können. Im Mittelpunkt sollte immer die Optimierung der Lebensqualität des Patienten stehen.

Abstract

Treatment of patients suffering from castration-resistant prostate cancer is a challenge for the attending physician. Due to the polysymptomatic nature of this disease, multidisciplinary cooperation (urology, radiation oncology, medical oncology, palliative care, orthopaedics, neurosurgery) is the centre of attention. Different surgical and radio-oncological therapeutic options are available based on different stages of this disease. Optimizing quality of life should always be the focus of attention in these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Aapro M, Abrahamsson PA, Body JJ et al (2008) Guidance on the use of bisphosphonates in solid tumors: recommendations of an international expert panel. Ann Oncol 19:420–432

    Article  PubMed  CAS  Google Scholar 

  2. Bubendorf L, Schopfer A, Wagner U et al (2000) Metastatic pattern of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 31:578–583

    Article  PubMed  CAS  Google Scholar 

  3. Chow E, Harris K, Fan G et al (2007) Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 25:1423–1436

    Article  PubMed  Google Scholar 

  4. Craine DS, Amling CL, Kane C (2004) Palliative transurethral prostate resection for bladder outlet obstruction in patients with locally advanced prostate cancer. J Urol 171:668–671

    Article  Google Scholar 

  5. De Puy V, Anstrom KJ, Castel LD et al (2007) Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer. Support Care Cancer 15:869–876

    Article  Google Scholar 

  6. Din OS, Thanvi N, Ferguson CJ et al (2009) Palliative prostate radiotherapy for symptomatic advanced prostate cancer. Radiother Oncol 93:192–196

    Article  PubMed  Google Scholar 

  7. Lankford SP, Pollack A, Zagars GK (1995) Radiotherapy for regionally localized hormone refractory prostate cancer. Int J Radiat Oncol Biol Phys 33:907–912

    Article  PubMed  CAS  Google Scholar 

  8. Lutz S, Berk L, Chang E et al (2011) Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys 79:965–976

    Article  PubMed  Google Scholar 

  9. Maan Z, Patel D, Moraitis K et al (2010) Comparison of stent-related symptoms between conventional Double-J stents and a new-generation thermoexpandable segmental metallic stent: a validated-questionnaire-based study. J Endourol 24:589–593

    Article  PubMed  Google Scholar 

  10. Moser L, Schubert T, Hinkelbein W (2008) Hormone-refractory and metastatic prostate cancer – palliative radiotherapy. Front Radiat Ther Oncol 41:117–125

    Article  PubMed  Google Scholar 

  11. Mottet N, Bellmunt J, Bolla M et al (2011) EAU Guidelines on Prostate Cancer, Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. Eur Urol 59:572–583

    Article  PubMed  Google Scholar 

  12. Pfister D, Porres D, Epplen R et al (2011) Palliative radikale (Zysto-) Prostatektomie bei lokal fortgeschrittenem kastrationsresistenten Prostatakarzinom. Urologe 50:1101–1105

    Article  PubMed  CAS  Google Scholar 

  13. Schmid HP (1991) The problem of obstruction in prostate cancer. Urol Res 19: 323–326

    Article  PubMed  CAS  Google Scholar 

  14. Todenhöfer T, Schwentner C, Schilling D et al (2011) Behandlung von ossären Metastasen und therapieinduzierter Osteoporose beim Prostatakarzinom. Urologe 50:1055–1063

    Article  PubMed  Google Scholar 

  15. Zantl N, Gschwend JE (2008) Stellenwert der Zystoprostatektomie beim local fortgeschrittenen Prostatakarzinom. Urologe 47:1447–1452

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Klinik für Urologie, Kantonsspital St. Gallen, Rorschacher Straße 95 , CH-9007, St. Gallen, Schweiz

    S. Preusser, P.M. Putora, L. Plasswilm & H.P. Schmid

Authors
  1. S. Preusser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P.M. Putora
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Plasswilm
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H.P. Schmid
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Preusser.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Preusser, S., Putora, P., Plasswilm, L. et al. Kastrationsresistentes Prostatakarzinom. Urologe 51, 27–31 (2012). https://doi.org/10.1007/s00120-011-2742-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-011-2742-0

Schlüsselwörter

Keywords

Search

Navigation