Skip to main content
SpringerLink
Log in

Epigenetik des Prostatakarzinoms

Untersuchung zellulärer Informationsträger jenseits der DNA-Sequenz

  • Leitthema
  • Published:
Der Urologe Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Feinberg AP, Vogelstein B (1983) Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301: 89–92

    Article  PubMed  CAS  Google Scholar 

  2. Nelson WG, De Marzo AM, Isaacs WB (2003) Prostate cancer. N Engl J Med 349: 366–381

    Article  PubMed  CAS  Google Scholar 

  3. Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415–428

    Article  PubMed  CAS  Google Scholar 

  4. Bastian PJ, Ellinger J, Heukamp LC et al. (2007) Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene Loci in patients undergoing radical prostatectomy. Eur Urol 51: 665–674

    Article  PubMed  CAS  Google Scholar 

  5. Bastian PJ, Ellinger J, Schmidt D et al. (2004) GSTP1 hypermethylation as a molecular marker in the diagnosis of prostatic cancer: is there a correlation with clinical stage, Gleason grade, PSA value or age? Eur J Med Res 9: 523–527

    PubMed  CAS  Google Scholar 

  6. Bastian PJ, Ellinger J, Wellmann A et al. (2005) Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci. Clin Cancer Res 11: 4097–4106

    Article  PubMed  CAS  Google Scholar 

  7. Yegnasubramanian S, Kowalski J, Gonzalgo ML et al. (2004) Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res 64: 1975–1986

    Article  PubMed  CAS  Google Scholar 

  8. Esteller M, Corn PG, Baylin SB, Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 61: 3225–3229

    PubMed  CAS  Google Scholar 

  9. Nakayama M, Bennett CJ, Hicks JL et al. (2003) Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 163: 923–933

    PubMed  CAS  Google Scholar 

  10. Bastian PJ, Palapattu GS, Lin X et al. (2005) Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy. Clin Cancer Res 11: 4037–4043

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Urologie, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freud-Straße 25, 53105, Bonn, Deutschland

    P.J. Bastian, J. Ellinger & S.C. Müller

  2. Institut für Pathologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Deutschland

    A. von Rücker

Authors
  1. P.J. Bastian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Ellinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S.C. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. von Rücker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P.J. Bastian.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bastian, P., Ellinger, J., Müller, S. et al. Epigenetik des Prostatakarzinoms. Urologe 46, 1080–1081 (2007). https://doi.org/10.1007/s00120-007-1433-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00120-007-1433-3

Search

Navigation